sjf620 — TargetMol Chemicals

Cat No.	Product Name	Targets
T13887	SJF620	Others
	SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).	Others
T74002	SJF620 hydrochloride	PROTACs
	SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].	PROTACs
T17319	1,2-Bis(2-iodoethoxy)ethane	Others , PROTAC Linker
	1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 and SJF620. MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, res...	Others , PROTAC Linker
T9408	N-piperidine Ibrutinib	BTK
	N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively. N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs, such as S...	BTK
T18066	Lenalidomide-OH	Ligand for E3 Ligase
	Lenalidomide-OH is a ligand of cereblon (CRBN), serving as an analog to Lenalidomide for E3 ubiquitin ligase. It is utilized in the recruitment of CRBN protein. Additionally, Lenalidomide-OH can be conjugated to a protei...	Ligand for E3 Ligase
T18068	Lenalidomide-PEG3-iodine	Others
	Lenalidomide-PEG3-iodine, an E3 ligase ligand-linker conjugate, consists of a cereblon-based Lenalidomide ligand and a 3-unit polyethylene glycol (PEG) linker. This compound is utilized in creating various proteolysis ta...	Others