Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lenalidomide-PEG3-iodine, an E3 ligase ligand-linker conjugate, consists of a cereblon-based Lenalidomide ligand and a 3-unit polyethylene glycol (PEG) linker. This compound is utilized in creating various proteolysis targeting chimeras (PROTACs), including the highly effective PROTAC BTK degrader SJF620, which has a degradation concentration 50 (DC50) of 7.9 nM[1].
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Description | Lenalidomide-PEG3-iodine, an E3 ligase ligand-linker conjugate, consists of a cereblon-based Lenalidomide ligand and a 3-unit polyethylene glycol (PEG) linker. This compound is utilized in creating various proteolysis targeting chimeras (PROTACs), including the highly effective PROTAC BTK degrader SJF620, which has a degradation concentration 50 (DC50) of 7.9 nM[1]. |
In vitro | Lenalidomide acts as a recruiter for the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). SJF620, a powerful PROTAC BTK degrader, integrates a BTK inhibitor with Lenalidomide via a linker, demonstrating its potent degradative capabilities[1]. |
Molecular Weight | 502.3 |
Formula | C19H23IN2O6 |
CAS No. | T18068 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Lenalidomide-PEG3-iodine T18068 Others LenalidomidePEG3iodine Lenalidomide-PEG-3-iodine Lenalidomide PEG3 iodine inhibitor inhibit