sik — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4599	HG-9-91-01	SIK inhibitor 1	SIK
	HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3respectively.		SIK
T17271	YKL-05-099		SIK
	YKL-05-099 is an inhibitor of the salt-inducible kinase(SIK1 and SIK3 ; IC50s: 10 and 30 nM, respectively). It has a slightly less potent SIK2-inhibitory (IC50:40 nM).		SIK
T9219	WH-4-025		AMPK , SIK
	WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.		AMPK , SIK
T5576	YKL-06-061		AMPK , SIK
	YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.		AMPK , SIK
T5993	ARN-3236		AMPK , SIK
	ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively). ARN-3236 Has anti-cancer activity.		AMPK , SIK
T4327	Prexasertib dihydrochloride	LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis , Chk , S6 Kinase
	Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.		Apoptosis , Chk , S6 Kinase
T4310	Prexasertib	LY2606368	Apoptosis , Chk
	Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.		Apoptosis , Chk
T78762	SIKs-IN-1
	SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2 macrophage polarization linked to inflammation. By inhibiting SIK...
T81156	Sikokianin E
	Sikokianin E, a biflavonone derivative, is isolable from Coreopsis tinctoria [1].
TN6420	Sikokianin A
	Sikokianin A shows in vitro antiviral activity against HBsAg secretion.
TN5830	Campsiketalin	Rengyoxide dimethyl ketal
	Campsiketalin is a natural product for research related to life sciences. The catalog number is TN5830 and the CAS number is 93675-96-8.
TN5021	Sikokianin C
	Sikokianin C is a biflavonoid isolated from Wikstroemia sikokiana.Sikokianin C is a selective cystathionine β-synthase inhibitor with antitumour activity for the treatment of human colon cancer.
T78196	SIK2-IN-1
	SIK2-IN-1 (compound 8g) is a potent inhibitor of SIK2 with selectivity over other AMPK-family kinases, demonstrating favorable ADMET profiles in vitro and robust cellular activities [1].
T61992	SIK1 activator 1
	SIK1 activator 1 can enhances the SIK1 phosphorylation and ameliorated the hyperglyceamia of type 2 diabetic mice. SIK1 activator 1 exhibited remarkable inhibitory activity on hepatic gluconeogenesis.
T1811	WH-4-023	KIN112,KIN001-112,Dual LCK/SRC inhibitor	Src
	WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK.		Src
T17272	YKL-06-062		SIK
	YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that inhibits SIK1, SIK2 and SIK3 with IC50s of 2.12 nM, 1.40 nM and 2.86 nM.		SIK
TP1760L	AMARA peptide acetate(163560-19-8 free base)		Others
	AMARA peptide acetate is a substrate for SIK and AMPK.AMARA peptide is a minimal substrate of several members of the protein kinases family. It consists of the phosphorylation site for AMP-activated Protein Kinase (AMPK)...		Others
T36891	MRIA9
	MRIA9, an ATP-competitive inhibitor targeting pan Salt-Inducible Kinases (SIK) and PAK2/3, demonstrates IC50 values of 516 nM, 180 nM, and 127 nM for SIK1, SIK2, and SIK3, respectively [1].
T75984	AMARA peptide TFA
	AMARA peptide (TFA) serves as a substrate for both salt-inducible kinase (SIK) and adenosine monophosphate-activated protein kinase (AMPK).
TP1314	AMARA peptide TFA (163560-19-8 free base)	AMARA peptide TFA
	AMARA peptide (TFA) is a substrate for salt-induced kinase (SIK) and adenosine activated protein kinase (AMPK).