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WH-4-025

Catalog No. T9219 CAS 1876463-35-2

WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.

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WH-4-025, CAS 1876463-35-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.

Molecular Weight	741.772
Formula	C39H38F3N7O5
CAS No.	1876463-35-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (164.47 mM, Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Brookline Avenue, et al. USES OF SALT-INDUCIBLE KINASE (SIK) INHIBITORS. Patent WO2016023014A2.

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

WH-4-025 1876463-35-2 PI3K/Akt/mTOR信号通路 AMPK SIK WH 4 025 inhibit Inhibitor WH4025 Salt-inducible Kinase (SIK) inhibitor

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