ptc — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2345	PTC-209	PTC209,PTC 209	BMI-1 , Autophagy
	PTC-209 is a potent and selective BMI-1 inhibitor.		BMI-1 , Autophagy
T16680	PTC-028		Apoptosis , BMI-1
	PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspas...		Apoptosis , BMI-1
T6178	PTC-209 hydrobromide	PTC-209 HBr	BMI-1 , Autophagy
	PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).		BMI-1 , Autophagy
T28470	PTC-510 TFA salt
	PTC-510 TFA salt inhibits hypoxia-induced VEGF expression.
T24682	PTC725	PTC-725,PTC 725
	PTC725 is a selective HCV 1b replicons inhibitor. It has been shown to target the nonstructural protein 4B.
T1805	Ataluren	PTC124	CFTR , Autophagy
	Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and olde...		CFTR , Autophagy
T12575	Unesbulin	PTC596	Apoptosis , BMI-1
	Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1).		Apoptosis , BMI-1
T12574	PTC299	Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate	VEGFR , Dehydrogenase
	PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA translation and selectively inhibits VEGF protein synthesis at t...		VEGFR , Dehydrogenase
T71552	ASC-JM-17
	ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. ASC-JM17 ameliorates toxicit...
T70942	AM-8508
	AM-8508 is a potent and selective PI3Kδ inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM ). AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibit KLH-specific a...
T78437	PTCDA
	PTCDA, an organic dye molecule, serves as an organic semiconductor [1].
T81355	PTC258
	PTC258 is a specific, orally active modulator of the splicing of the Elongator complex protein 1 gene (ELP1), enhancing its expression both in vitro and in vivo. Additionally, PTC258 has demonstrated good tolerability in...
T3448	GJ103		Others
	GJ103 sodium salt is an active analog of the read-through compound GJ072. Some GJ072 analogs (e.g., GJ103, GJ106, GJ109, and GJ111) consistently demonstrates their activities in all three PTCs by both FCATMpSer1981 and I...		Others
T34426	RTC14	Read-through compound-14,RTC 14,RTC-14,Read-through compound 14
	RTC14, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.
T34425	RTC13	Read-through compound 13,RTC 13,RTC-13
	RTC13, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.
T70944	Carotegrast methyl HCl
	Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the α4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM30...
T61306	SRI-41315
	SRI-41315, a chemical compound, effectively addresses premature termination codons (PTCs) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells. It induces a prolonged pause at stop...

Compounds

PTC-209

T2345

Synonym: PTC209,PTC 209

Target: BMI-1, Autophagy

PTC-028

T16680

Synonym:

Target: Apoptosis, BMI-1

PTC-209 hydrobromide

T6178

Synonym: PTC-209 HBr

Target: BMI-1, Autophagy

Synonym: PTC-725,PTC 725

Target: CFTR, Autophagy

Unesbulin

T12575

Synonym: PTC596

Target: Apoptosis, BMI-1

PTC299

T12574

Synonym: Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate

Target: VEGFR, Dehydrogenase

Synonym: Read-through compound-14,RTC 14,RTC-14,Read-through compound 14

Target:

RTC13

T34425

Synonym: Read-through compound 13,RTC 13,RTC-13

Target:

Carotegrast methyl HCl

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02215	Coagulation factor IX/F9 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Coagulation factor IX/F9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is AAB59620.1.
TMPY-05355	Coagulation factor IX/F9 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Coagulation factor IX/F9 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.5 kDa and the accession number is P00740-1.
TMPY-02270	RET Protein, Human, Recombinant (His)	Human	HEK293 Cells
	RET Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.1 kDa and the accession number is P07949-1.
TMPY-04418	RET Protein, Human, Recombinant (aa 658-1114, His & GST)	Human	Baculovirus Insect Cells
	RET Protein, Human, Recombinant (aa 658-1114, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.7 kDa and the accession number is P07949-1.
TMPH-01946	PTCH2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	PTCH2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-01528	IHH Protein, Human, Recombinant (His)	Human	E. coli
	Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target gen...