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Search Results for " pac1 "

13

Compounds

Cat No. Product Name Synonyms Targets
T2503 PAC-1 Procaspase activating compound 1 Apoptosis , Caspase , Autophagy
PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers, among others.
T78105 PAC1R antagonist 1 PACAP
PAC1R antagonist 1 is an orally active PAC1 receptor antagonist that inhibits abnormal pain induced by pituitary adenylate cyclase-activating polypeptide (PACAP) and nerve damage, and may be used in the study of neoplasm...
T18603 PROTAC BRD4 degrader for PAC-1 Others
PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective pro...
TP1618L PACAP-38 (31-38), human, mouse, rat acetate PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base) PACAP
PACAP-38 (31-38), human, mouse, rat acetate is an activator of PAC1 receptor. PACAP-38 (31-38), human, mouse, rat acetate demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY an...
T41005 PA-8 PACAP
PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vp...
T76949 Zelminemab
Zelminemab (AMG-301) is a human monoclonal antibody designed to target and inhibit the PACAP type I (PAC1) receptor [1].
TP2071 Bay 55-9837
Selective VPAC2 receptor agonist (EC50 values are 0.4, 100 and >1000 nM for VPAC2, VPAC1 and PAC1, respectively in a cAMP accumulation assay; IC50 values are 60, 8700 and >10000 nM for VPAC2, VPAC1 and PAC1, respectively...
T24585 PA-9 PA 9
PA-9 is the first small-molecule PAC1 receptor antagonist.
T81891 M65
M65 is a PAC1 receptor-specific antagonist that inhibits the secretion of atrial natriuretic peptide (ANP) [1].
T29140 VU0652925 VU 0652925,BMS-3,VU-0652925,BMS3,BMS 3
VU0652925 is a PAR4 antagonist. VU0652925 has a P-sel IC50 of 39.2 pM (-pIC50±SEM: 10.41±0.04) and a PAC1 IC50 of 43.0 pM (-pIC50±SEM: 10.4±0.04).
TP1069 PACAP (1-27), human, ovine, rat TFA PACAP 1-27 TFA
PACAP (1-27), human, ovine, rat TFA (PACAP 1-27 TFA) is an N-terminal fragment of pacap-38 and an effective PACAP receptor antagonist. The IC50s for rat PAC1, rat VPAC1 and human VPAC2 are 3nm, 2nm and 5nm respectively.
T36427 PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt) PACAP
Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expres...
TP1878 PACAP (1-38), human, ovine, rat Pituitary Adenylate Cyclase Activating Polypeptide 38,PACAP 1-38 PACAP
PACAP (1-38), human, ovine, rat (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a neuropeptide with 38 amino acid residues.
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