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PACAP-38 (31-38), human, mouse, rat acetate

Catalog No. TP1618L

Synonyms: PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base)

PACAP-38 (31-38), human, mouse, rat acetate is an activator of PAC1 receptor. PACAP-38 (31-38), human, mouse, rat acetate demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production and can

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PACAP-38 (31-38), human, mouse, rat acetate Chemical Structure

PACAP-38 (31-38), human, mouse, rat acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 137.00
5 mg	In stock	$ 412.00
10 mg	In stock	$ 597.00
25 mg	In stock	$ 953.00
50 mg	In stock	$ 1,290.00
100 mg	In stock	$ 1,730.00
500 mg	In stock	$ 3,490.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

PACAP-38 (31-38), human, mouse, rat acetate (0.01-10 nM; HEK 293 cells) stimulates neural cells to express endogenous PAC1 receptors by cAMP accumulation and by an increase in cytosolic free calcium and induces elevation of the intracellular Ca2+ concentration in a dose-dependent manner with an EC50 value of 0.81 nM. PACAP-38 (31-38), human, mouse, rat acetate (300 nM; 4 h) stimulates the generation of APPsα in neural cells[1]. PACAP-38 (31-38), human, mouse, rat acetate (0.01 nM; 48 h) elicits potent and efficacious stimulation of NPY secretion from SCG neuronal cultures[2]. PACAP-38 (31-38), human, mouse, rat acetate (100 nM; 14 d) produces sustained stimulated NPY and catecholamine secretionmpathetic neurons[2]. PACAP-38 (31-38), human, mouse, rat acetate (100 nM; 2 min; NCI-H838 cells) induces EGFR, HER2, and ERK tyrosine phosphorylation. PACAP-38 (31-38), human, mouse, rat acetate (10 nM; 48 h) stimulates the growth of NCI-H838 cells. PACAP-38 (31-38), human, mouse, rat acetate (100 nM; 30 min; NCI-H838 cells) induces EGFR tyrosine phosphorylation with generates ROS and increases ROS levels by 51%[3].

Synonyms	PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base)
Molecular Weight	1122.32
Formula	C49H87N17O13

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kojro E, et, al. The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein. FASEB J. 2006 Mar;20(3):512-4. 2. Braas KM, et, al. Pituitary adenylate cyclase-activating polypeptides, PACAP-38 and PACAP-27, regulation of sympathetic neuron catecholamine, and neuropeptide Y expression through activation of type I PACAP/VIP receptor isoforms. Ann N Y Acad Sci. 1996 Dec 26;805:204-16; discussion 217-8. 3. Moody TW, et, al. PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner. Peptides. 2019 Oct;120:170017.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library

Related Products

Related compounds with same targets

PACAP (1-27), human, ovine, rat acetate PACAP 1-38 acetate PACAP-related Peptide (rat) (trifluoroacetate salt) PAC1R antagonist 1 PACAP (6-38), human, ovine, rat acetate PACAP-related Peptide (human) (trifluoroacetate salt) PA-8 PACAP (1-38), human, ovine, rat

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PACAP-38 (31-38), human, mouse, rat acetate GPCR/G Protein PACAP PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base) PACAP-38 , human, mouse, rat Acetate PACAP38 (3138), human, mouse, rat acetate PACAP 38 (31 38), human, mouse, rat acetate inhibitor inhibit

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