nsd2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8879	MR837	ZINC30303842,NSD2-PWWP1 antagonist 3f	Others , Histone Methyltransferase
	MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.		Others , Histone Methyltransferase
T62705	NSD2-IN-1
	NSD2-IN-1 (compound 38) serves as a potent and highly selective inhibitor of NSD2-PWWP1 (nuclear receptor-binding SET domain 2-PWWP1), demonstrating an IC50 value of 0.11 μM. By binding to NSD2-PWWP1, NSD2-IN-1 impacts t...
T79617	NSD2-IN-4		Histone Methyltransferase
	NSD2-IN-4 is a potent, selective inhibitor of the NSD2-SET domain, showing promise for the treatment of diseases related to NSD2 [1].		Histone Methyltransferase
T9006	LEM-14		Others
	LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.		Others
T72979	LEM-14-1189		Histone Methyltransferase
	Lem-14-1189, a LEM-14 derivative, is a potent NSD inhibitor of the nuclear receptor binding SET domain, and has inhibitory effects on NSD1, NSD2, and NSD3, with IC50 of 418 μM, 111 μM, and 60 μM, respectively. LEM-14-118...		Histone Methyltransferase
T9584	UNC6934		Others , Histone Methyltransferase
	UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.		Others , Histone Methyltransferase
T12263L	NSC305787 hydrochloride	(Rac)-NSC305787 hydrochloride	Others
	NSC305787 hydrochloride ((Rac)-NSC305787 hydrochloride is a cell membrane permeable and selective and potent small molecule dual inhibitor of Cdc25 dual specificity phosphatase and EZR that displays antitumor activity in...		Others
T79616	UNC7096		Histone Methyltransferase
	UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1].		Histone Methyltransferase
T77967	MS159		PROTACs
	MS159 is a potent PROTAC degrader targeting the nuclear receptor binding SET structural domain protein 2 (NSD2), which inhibits tumor cell growth. This compound serves as a valuable chemical tool for investigating NSD2's...		PROTACs
T12083	MMSET-IN-1		Others
	MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) .		Others
T83867	UNC8153 TFA
	UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a 50% degradation constant (DC50) of 350 nM. At a concentrati...
T10538	BI-9321		Others
	BI-9321 is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2.		Others
T10538L	BI-9321 trihydrochloride		Others
	BI-9321 trihydrochloride is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2.		Others
T36802	Bisubstrate Inhibitor 78
	Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50= 1.41 μM).1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinam...
T36978	AS-99 TFA
	AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and different...
T36977	AS-99 free base
	AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, ...