Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-9321 trihydrochloride is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2.
Description | BI-9321 trihydrochloride is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. |
Targets&IC50 | NSD3-PWWP1:(kd)166 nM |
In vitro | BI-9321 trihydrochloride specifically disrupts histone interactions of the NSD3-PWWP1 domain (IC50: 1.2 μM in U2OS cells). BI-9321 is targeting the methyl-lysine binding site of the PWWP1 domain and cellular target engagement at 1?μM. BI-9321 downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells. |
Molecular Weight | 469.81 |
Formula | C22H24Cl3FN4 |
CAS No. | 2387510-87-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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BI-9321 trihydrochloride 2387510-87-2 Others BI9321 BI-9321 Trihydrochloride BI 9321 trihydrochloride BI-9321 BI9321 trihydrochloride BI 9321 Trihydrochloride BI9321 Trihydrochloride BI 9321 inhibitor inhibit