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Cat No. | Product Name | Synonyms | Targets |
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T78699 | MDMX/MDM2-IN-2 | ||
MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, demonstrating dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX. It effectively disrupts the interaction between p53 and MDM2 proteins, ther... | |||
T6610 | XI-006 | NSC 207895 | Mdm2 , p53 |
XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. | |||
T16888 | SJ-172550 | Mdm2 , E1/E2/E3 Enzyme | |
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM). | |||
T16771 | RO-5963 | Mdm2 , p53 | |
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively). | |||
T12257 | NSC 146109 hydrochloride | Apoptosis , Others | |
NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer. | |||
T28078 | MMRi64 | Apoptosis , Mdm2 , p53 | |
MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2... | |||
T24041 | WK-298 | WK 298 | |
WK-298 is an effective MDM2/MDMX-p53 interaction inhibitor. | |||
T70726 | RO2443 | ||
RO2443 is a dual inhibitor of the MDM2-p53 or MDMX-p53 protein-protein interaction, inducung MDM2 and MDMX dimerization and activating the p53 pathway. | |||
T76569 | Sulanemadlin | ||
Sulanemadlin (ALRN-6924) is a potent peptidomimetic macrocycle that serves as an inhibitor of the p53-MDM2 and p53-MDMX protein-protein interactions. It is capable of inhibiting either or both of these interactions, posi... | |||
T70611 | ATSP-7041 | ||
ATSP-7041 is a novel potent and selective dual inhibitor of mdm2 (ki = 0.9 nm) and mdmx (ki = 7 nm) |
Cat No. | Product Name | Species | Expression System |
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TMPY-01125 | MDMX Protein, Human, Recombinant (His) | Human | E. coli |
MDM4 (MDM4 Regulator Of P53, also known as MDMX) is a Protein Coding gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows str... |