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MMRi64

Catalog No. T28078 CAS 430458-66-5

MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2 and MdmX in leukemia cells.MMRi64 MMRi64 can be used in cancer research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MMRi64, CAS 430458-66-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 193.00
25 mg	In stock	$ 333.00
50 mg	In stock	$ 497.00
100 mg	In stock	$ 693.00
500 mg	In stock	$ 1,450.00

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Purity: 99.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	410.3
Formula	C22H17Cl2N3O
CAS No.	430458-66-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wu W, et al. Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells. Cell Death Dis. 2015;6(12):e2035.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MMRi64 430458-66-5 Apoptosis Mdm2 p53 MMRi-64 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.