mdk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T28001	MDK-6983	MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983	Autophagy
	MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.		Autophagy
T19765	MDK-4025		Calcium Channel
	MDK-4025 is an inhibitor of the high voltage-activated (HVA) Ca2+ current in pyramidal neurons.		Calcium Channel
T25779	MDK-4683	MDK 4683,CA IX/XII Inhibitor
	MDK-4683, also known as CA IX/XII Inhibitor, is a hCA IX and hCA XII inhibitor.
T33261	MDK-5432	AMPA stabilizer (R,R)-2a,MDK 5432
	MDK-5432, also known as AMPA stabilizer (R,R)-2a, is the most potent AMPA stabilizer.
T25780	MDK-4823	LMPTP-IN-23,LMPTP-IN 23,MDK4823,LMPTP-IN23,MDK 4823
	MDK-4823, also known as LMPTP inhibitor1, is a potent low-molecular-weight tyrosine phosphatase (LMPTP) inhibitor. LMPTP is highly expressed in insulin-target tissues. LMPTP promotes diabetes and insulin resistance in ob...
T5310	TR-14035	MDK-1191	Integrin
	TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).		Integrin
T27998	MDK-4204	Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I
	MDK-4204, an anticancer agent, shows significant anti-cancer activity with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively.
T27997	MDK-3345	MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11
	MDK-3345 is a reversible covalent inhibitor for Mcl-1.
T27999	MDK-4624	AMPKα1 activator C13,C13, Compound 13
	MDK-4624 is a AMPKα1 activator. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 potently i...
T27991	MDK-0757	Hsp90-IN-89,MDK0757
	MDK-0757 is a novel inhibitor of heat shock protein 90 (Hsp90).
T5093	Pim1/AKK1-IN-1	LKB1/AAK1 dual inhibitor,MDK-2275	Pim , Hippo pathway
	Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.		Pim , Hippo pathway
T27990	MDK-0738	AKR1C3-IN-14a,AKR1C3 IN 14a
	MDK-0738 is a potent and selective aldo-keto reductase 1C3 inhibitor.
T27995	MDK-3046	HK-inhibitor-2,MDK3046,HK inhibitor 2
	MDK-3046 is a YycG histidine kinase (HK) inhibitor with potent antibiofim activity against Staphylococcus epidermidis.
T27994	MDK-2959	PTPsigma inhibitor2,PTPsigma inhibitor 2,PTPsigmainhibitor2
	MDK-2959 is a potent inhibitor of protein tyrosine phosphatase sigma (PTPsigma).
T27996	MDK-3298	Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5
	MDK-3298 is a reversible covalent inhibitor of Mcl-1, a target of protein-protein interaction (PPI).
T27992	MDK08445	MDK-08445,MDK 08445
	MDK08445 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic.
T28000	MDK49781	MDK-49781,MDK 49781
	MDK49781 is a useful chemical intermediate for drug synthesis.
T1772	MDK83190	Apoptosis Activator 2	Apoptosis , Caspase
	MDK83190 (Apoptosis Activator 2) is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .		Apoptosis , Caspase
T28002	MDK71803	MDK-71803,Cefiderocol-intermediate, Cefiderocol-precursor,MDK 71803
	MDK71803 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain.
T28004	MDK8228	PF-CBP/BRD4,MDK-8228,MDK 8228
	MDK8228 is an inhibitor of CBP/p300 and BRD4 bromodomain. MDK8228 downregulates IL-6, IL-ß and IFN-ß in macrophages.