map4k — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TQ0079	GNE-495		MAPK
	GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).		MAPK
T11942	MAP4K4-IN-3	Compound 17	MAPK
	MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.		MAPK
T4011	NCB-0846	NCB 0846	MAPK , Wnt/beta-catenin
	NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).		MAPK , Wnt/beta-catenin
T5643	NG25		MAPK
	NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.		MAPK
T11793	KY-05009		Wnt/beta-catenin
	KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o...		Wnt/beta-catenin
T9470	HPK1-IN-7		MAPK
	HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).		MAPK
T5483	DMX-5804	DMX-5084	MAPK
	DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice.		MAPK
T11438	GNE-1858		Others , MAPK
	GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).		Others , MAPK
T4221	PF-06260933	PF-6260933,PF 6260933,PF6260933	MAPK
	PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.		MAPK
T10444	TAK1/MAP4K2 inhibitor 1		Others
	TAK1/MAP4K2 inhibitor 1 is a potent dual inhibitor of TGFβ-activated kinase 1 (TAK1) and MAP4K2 (IC50s: 41.1 nM and 18.2 nM).		Others
T79794	TNIK&MAP4K4-IN-1
	TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor targeting TNIK and MAP4K4/HGK, exhibiting IC50 values of 1.29 nM and <10 nM, respectively, in human hepatic stellate cell LX-2. This compound is applicable in t...
T63659	HPK1-IN-10
	HPK1-IN-10 is a potent inhibitor of HPK1, a serine/threonine protein kinase cloned from hematopoietic progenitor cells and a member of the MAP4K family of mammalian Ste-20-associated protein kinases. HPK1-IN-10 has poten...
T63670	HPK1-IN-9
	HPK1-IN-9 is a potent HPK1 inhibitor. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and is a member of the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-10 has p...
T61449	HPK1-IN-18
	HPK1-IN-18 is a highly effective and specific HPK1 inhibitor. HPK1, a MAP kinase kinase kinase kinases (MAP4K) member, was initially isolated from hematopoietic progenitor cells. This compound, known as HPK1-IN-18, is va...
T62645	HPK1-IN-14
	HPK1-IN-14 is a potent inhibitor of HPK1. HPK1-IN-14 has potential for the study of HPK1-related diseases.
T62628	HPK1-IN-12
	HPK1-IN-12 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.
T62629	HPK1-IN-13
	HPK1-IN-13 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.
T62742	HPK1-IN-11
	HPK1-IN-11 is a potent HPK1 inhibitor. HPK1-IN-11 has potential for the study of HPK1-related diseases.