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NG25

Catalog No. T5643   CAS 1315355-93-1

NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
NG25 Chemical Structure
NG25, CAS 1315355-93-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 84.00
2 mg In stock $ 119.00
5 mg In stock $ 197.00
10 mg In stock $ 297.00
25 mg In stock $ 598.00
50 mg In stock $ 853.00
100 mg In stock $ 1,180.00
500 mg In stock $ 2,350.00
1 mL * 10 mM (in DMSO) In stock $ 252.00
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Purity: 99.46%
Purity: 98%
Purity: 97.59%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
Targets&IC50 MAP4K2:21.7 nM, TAK1:149 nM
In vitro NG25 sensitizes the breast cancer cells to Dox treatment in vitro. This combination may be an effective and feasible therapeutic option maximizing Dox efficacy and meanwhile minimizing Dox side effects in treating breast cancer[1].
Cell Research Breast cancer cells were seeded in 12-well plates at 2?×?10^3 cells per well, then incubated with Dox alone or Dox with NG25 at indicated concentrations after 72?h and then were cultured in fresh medium without drug.?Two weeks later, cells were fixed and stained with methanol/crystal violet for 10?min, and photographed.?Each experiment was performed in triplicates[1].
Molecular Weight 537.58
Formula C29H30F3N5O2
CAS No. 1315355-93-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (186.02 mM)

TargetMolReferences and Literature

1. Wang Z , Zhang H , Shi M , et al. TAK1 inhibitor NG25 enhances doxorubicin-mediated apoptosis in breast cancer cells[J]. Scientific Reports, 2016, 6:32737. 2. Pauls E , Shpiro N , Peggie M , et al. Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells *[J]. Journal of Biological Chemistry, 2012, 287.

TargetMolCitations

1. Fan S, Huang X, Tong H, et al. p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression. European Journal of Pharmacology. 2022: 175277.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Prostate Cancer Compound Library Anti-Ovarian Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library Immunology/Inflammation Compound Library Neural Regeneration Compound Library Kinase Inhibitor Library Anti-Colorectal Cancer Compound Library Anti-Obesity Compound Library Osteogenesis Compound Library

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Keywords

NG25 1315355-93-1 MAPK NG-25 NG 25 MAP kinase kinase kinase, MEKK, MAPKKK MAP4K inhibit Inhibitor MAP3K MAPK Kinase Kinase Kinase inhibitor

 

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