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MAPK MAPK NG25

NG25

Catalog No. T5643   CAS 1315355-93-1

NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.

NG25, CAS 1315355-93-1
Pack Size Availability Price/USD Quantity
2 mg In Stock 112.00
5 mg In Stock 222.00
10 mg In Stock 333.00
25 mg In Stock 665.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
Targets&IC50 TAK1 ,   MAP4K2
In vitro NG25 sensitizes the breast cancer cells to Dox treatment in vitro. This combination may be an effective and feasible therapeutic option maximizing Dox efficacy and meanwhile minimizing Dox side effects in treating breast cancer[1].
Cell Research
Breast cancer cells were seeded in 12-well plates at 2 × 10^3 cells per well, then incubated with Dox alone or Dox with NG25 at indicated concentrations after 72 h and then were cultured in fresh medium without drug. Two weeks later, cells were fixed and stained with methanol/crystal violet for 10 min, and photographed. Each experiment was performed in triplicates[1].
Molecular Weight 537.58
Formula C29H30F3N5O2
CAS No. 1315355-93-1

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 100 mg/mL (186.02 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Wang Z , Zhang H , Shi M , et al. TAK1 inhibitor NG25 enhances doxorubicin-mediated apoptosis in breast cancer cells[J]. Scientific Reports, 2016, 6:32737. 2. Pauls E , Shpiro N , Peggie M , et al. Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells *[J]. Journal of Biological Chemistry, 2012, 287.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Stem cell Differentiation Compound Library Apoptosis Compound Library MAPK Inhibitor Library Immunology/Inflammation Compound Library Kinase Inhibitor Library TGF-beta/Smad Compound Library Anti-obesity Compound Library Anti-aging Compound Library HIF-1 Signaling Pathway Compound Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Cytoskeletal Signaling Pathway Compound Library

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.