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GNE-495

Catalog No. TQ0079   CAS 1449277-10-4

GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).

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GNE-495 Chemical Structure
GNE-495, CAS 1449277-10-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 66.00
5 mg In stock $ 97.00
10 mg In stock $ 148.00
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Purity: 99.22%
Purity: 98.23%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).
Targets&IC50 MAP4K4:3.7nM
In vitro GNE-495 has efficacy in retinal angiogenesis. GNE-495 shows the best balance of MAP4K4 inhibition, permeability, microsomal stability, and cellular potency.
In vivo GNE-495 is administered intraperitoneally to neonatal mouse pups at high doses: 25 and 50 mg/kg. GNE-495 shows excellent potency and good PK in vivo profile in all species tested, with low clearances, moderate terminal half-lives, and reasonable oral exposure levels (F=37-47%).
Molecular Weight 405.42
Formula C22H20FN5O2
CAS No. 1449277-10-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2 mg/mL (4.93 mM), sonification is recommended.

TargetMolReferences and Literature

1. Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Osteogenesis Compound Library Kinase Inhibitor Library Anti-Liver Cancer Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compound Library MAPK Inhibitor Library HIF-1 Signaling Pathway Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GNE-495 1449277-10-4 MAPK MAPK Kinase Kinase Kinase GNE495 MAP4K inhibit GNE 495 Inhibitor inhibitor

 

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