Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 66.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 148.00 |
Description | GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM). |
Targets&IC50 | MAP4K4:3.7nM |
In vitro | GNE-495 has efficacy in retinal angiogenesis. GNE-495 shows the best balance of MAP4K4 inhibition, permeability, microsomal stability, and cellular potency. |
In vivo | GNE-495 is administered intraperitoneally to neonatal mouse pups at high doses: 25 and 50 mg/kg. GNE-495 shows excellent potency and good PK in vivo profile in all species tested, with low clearances, moderate terminal half-lives, and reasonable oral exposure levels (F=37-47%). |
Molecular Weight | 405.42 |
Formula | C22H20FN5O2 |
CAS No. | 1449277-10-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2 mg/mL (4.93 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GNE-495 1449277-10-4 MAPK MAPK Kinase Kinase Kinase GNE495 MAP4K inhibit GNE 495 Inhibitor inhibitor