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NCB-0846

Name: NCB-0846
Brand: TargetMol
SKU: T4011
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4011Cas No. 1792999-26-8

Alias NCB 0846

NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).

NCB-0846

🥰Excellent

Purity: 99.89%

Catalog No. T4011Alias NCB 0846Cas No. 1792999-26-8

NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$263	In Stock
50 mg	$447	In Stock
100 mg	$659	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Batch Information

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Purity:99.89%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
Targets&IC50	TNIK:21 nM
In vivo	Sixty normal male and female volunteers between 18 and 40 years of age were recruited for a double-masked, placebo-controlled, crossover study in which each eye of each subject was dilated with 2.5% phenylephrine. After one hour, one eye was treated with 0.5% dapiprazole, and the contralateral eye was treated with placebo.
Synonyms	NCB 0846

Chemical Properties

Molecular Weight	375.42
Formula	C₂₁H₂₁N₅O₂
Cas No.	1792999-26-8
Smiles	O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4nc[nH]c4c3)nc12
Relative Density.	1.415 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (133.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6637 mL	13.3184 mL	26.6368 mL	133.1842 mL
5 mM	0.5327 mL	2.6637 mL	5.3274 mL	26.6368 mL
10 mM	0.2664 mL	1.3318 mL	2.6637 mL	13.3184 mL
20 mM	0.1332 mL	0.6659 mL	1.3318 mL	6.6592 mL
50 mM	0.0533 mL	0.2664 mL	0.5327 mL	2.6637 mL
100 mM	0.0266 mL	0.1332 mL	0.2664 mL	1.3318 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc