lsd1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2315	GSK-LSD1 dihydrochloride	GSK-LSD1 (hydrochloride),GSK-LSD1 2HCl	Histone Demethylase
	GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, ...		Histone Demethylase
T77635	LSD1-IN-27		Histone Demethylase , PD-1/PD-L1
	LSD1-IN-27 is a potent LSD1 inhibitor with an IC50 value of 13 nM.LSD1-IN-27 inhibited the stemness and migration of gastric cancer cells.LSD1-IN-27 inhibited the expression of PD-L1 in BGC-823 and MFC cells.LSD1-IN-27 p...		Histone Demethylase , PD-1/PD-L1
T11882	Pulrodemstat benzenesulfonate	LSD1-IN-7 benzenesulfonate,CC-90011 benzenesulfonate	Histone Demethylase
	Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity.		Histone Demethylase
T63140	LSD1-IN-20		Histone Demethylase
	Lsd1-in-20 is a potent dual inhibitor of LSD1/G9a with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 showed antiproliferative activity against THP-1 leukemia cells and MDA-MB-231 breast cancer cells in vitro, w...		Histone Demethylase
T83966	LSD1-IN-30		Histone Demethylase
	LSD1-IN-30 is a lysine-specific demethylase 1 (LSD1) inhibitor with anticancer activity for the study of small cell lung cancer and acute myeloid leukemia.		Histone Demethylase
T36625	LSD1/HDAC6-IN-1	LSD1/HDAC6-IN-1
	LSD1/HDAC6-IN-1 is an orally active compound that functions as a dual inhibitor, targeting lysine specific demethylase 1 (LSD1) and histone deacetylase 6 (HDAC6). This compound demonstrates promising anti-tumor activity ...
T67871	LSD1-IN-24		Histone Demethylase , PD-1/PD-L1
	LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases.		Histone Demethylase , PD-1/PD-L1
T11880	LSD1-IN-5		Histone Demethylase
	LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-5 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 121 nM.		Histone Demethylase
T11881	LSD1-IN-6		Histone Demethylase
	LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-6 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 123 nM.		Histone Demethylase
T82254	GSK-LSD1		Histone Demethylase
	GSK-LSD1, an LSD1 inhibitor, decreases food consumption and body weight while enhancing insulin sensitivity and glycemic regulation in murine obesity models. Additionally, it mitigates non-alcoholic fatty liver disease (...		Histone Demethylase
T11883	Pulrodemstat Methylbenzenesulfonate	LSD1-IN-7 Methylbenzenesulfonate	Others
	LSD1-IN-7 Methylbenzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity.		Others
T74855	LSD1-IN-25		Histone Demethylase
	LSD1-IN-25 (Compound 9j) is a potent, selective, and orally active inhibitor of LSD1, exhibiting an IC50 of 46 nM (Ki = 30.3 nM) and capable of inducing apoptosis in cancer cells [1].		Histone Demethylase
T78888	LSD1-UM-109		Histone Demethylase
	LSD1-UM-109 is a highly potent and reversible inhibitor of LSD1, demonstrating an IC50 of 3.1 nM. This compound exhibits strong antiproliferative activity, inhibiting cell growth with IC50 values of 0.6 nM in the MV4;11 ...		Histone Demethylase
T60381	LSD1-IN-12
	LSD1-IN-12 (compound 2) is an effective inhibitor of LSD1, demonstrating inhibitory Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively [1].
T60362	LSD1-IN-22
	LSD1-IN-22 is a potent inhibitor of Lysine-specific demethylase 1 ( LSD1 ) with a K i value of 98 nM. LSD1-IN-22 has anti-proliferative activity against certain cancer cells [1].
T60941	LSD1-IN-15
	LSD1-IN-15 (compound 1b) is a potent LSD1 inhibitor that inhibit LSD1-CoREST, MAO-A and MAO-B with IC 50 values of 0.149, 0.028, and 0.327 μM, respectively. LSD1-IN-15 shows cell growth arrest in LNCaP cells of prostate ...
T62674	LSD1-IN-21
	LSD1-IN-21 is a potent, blood-brain barrier permeable LSD1 (lysine specific demethylase-1) inhibitor (IC50: 0.956 μM).LSD1-IN-21 significantly reduces the pro-inflammatory cytokine TNF-α and exhibits good anti-cancer and...
T74858	LSD1-IN-26
	LSD1-IN-26 (compound 12u), a potent LSD1 inhibitor, exhibits an IC50 of 25.3 nM. It also demonstrates inhibition of MAO-A (IC50 = 1234.57 nM) and MAO-B (IC50 = 3819.27 nM), significantly inducing apoptosis in MGC-803 cel...
T61021	LSD1-IN-16
	LSD1-IN-16 (compound 4b) is a potent inhibitor of LSD1 that inhibits LSD1-CoREST, MAO-A and MAO-B with IC50 values of 0.015, 0.024, and 0.366 μM, respectively. LSD1-IN-16 exhibits cell growth arrest in prostate cancer LN...
T61022	LSD1-IN-17
	LSD1-IN-17 (compound 5b) is a potent inhibitor of LSD1 that inhibits LSD1-CoREST, MAO-A and MAO-B, with IC 50 values of 0.005, 0.028, and 0.820 μM, respectively. LSD1-IN-17 exhibits cell growth arrest in prostate cancer ...