20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1835 | Ibrutinib | PCI-32765 | Tyrosine Kinases , Src , BTK , Ligands for Target Protein for PROTAC |
Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation. | |||
T12152 | N-piperidine Ibrutinib hydrochloride | BTK | |
N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor, a BTK ligand, inhibits WT BTK and C481S BTK, which can be used to synthesize a range of PROTAC molecules.N-piperidine Ibrutinib hydrochloride has potential ... | |||
T9408 | N-piperidine Ibrutinib | BTK | |
N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively. N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs, such as S... | |||
T8636 | Ibrutinib deacryloylpiperidine | IBT4A,5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine | BTK |
Ibrutinib deacryloylpiperidine (IBT4A) is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM. | |||
T11601 | Ibrutinib-d5 | PCI-32765 D5,Ibrutinib D5 | Others |
Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor. | |||
T18049 | Ibrutinib-biotin | Others | |
Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, has an IC50 of 0.755-1.02 nM for BTK. | |||
T11602 | Ibrutinib dimer | Others | |
Ibrutinib dimer is an impurity of Ibrutinib. IIbrutinib dimer is a Dimer of Ibrutinib. Ibrutinib is an irreversible Btk inhibitor (IC50: 0.5 nM). | |||
T36429 | Dihydrodiol-Ibrutinib | ||
PCI 45227 is an active metabolite of the Bruton's tyrosine kinase inhibitor ibrutinib .1PCI 45227 is formed from ibrutinib by the cytochrome P450 (CYP) isoform CYP3A. 1.Veeraraghavan, S., Viswanadha, S., Thappali, S., et... | |||
T16440 | Ibrutinib Racemate | PCI-32765 (Racemate) | Others |
Ibrutinib is a selective, irreversible Btk inhibitor (IC50: 0.5 nM). Ibrutinib Racemate is the racemate of Ibrutinib. | |||
T11603 | Ibrutinib-MPEA | Others | |
Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible BTK inhibitor that has been used to treat hematological malignancies. | |||
T21357 | Ibrutinib Interm 0441 | (S)-1-Boc-3-hydroxypiperidine,(S)-1-Boc-3-piperidinol | |
Ibrutinib Interm 0441 is a piperidine derivative with an amine protecting group and may be used in the preparation of biologically active compounds. | |||
T16730 | Remibrutinib | BTK | |
Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50: 1 nM). Remibrutinib has the potential for Chronic urticar... | |||
T10625 | IBT6A | BTK | |
IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. | |||
T10626 | (Rac)-IBT6A | Others , BTK | |
(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. | |||
T10625L | (Rac)-IBT6A hydrochloride (1412418-47-3 free base) | (Rac)-IBT6A hydrochloride | Others |
(Rac)-IBT6A hydrochloride is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib. IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). | |||
T10625L2 | IBT6A hydrochloride | Others | |
IBT6A hydrochloride is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. | |||
T73942 | (Rac)-IBT6A hydrochloride | ||
(Rac)-IBT6A hydrochloride is a racemic mixture comprising IBT6A hydrochloride, which itself is an impurity of Ibrutinib. This compound plays a role in the synthesis of both the IBT6A Ibrutinib dimer and the IBT6A adduct ... | |||
T73275 | BTK-IN-22 | ||
BTK-IN-22, a BTK inhibitor (IC 50: 0.9 nM), also exhibits inhibition against BLX and BMX with IC 50 values of 1.4 and 1.2 nM, respectively. Demonstrating enhanced kinase selectivity, BTK-IN-22 outperforms Ibrutinib in th... | |||
T70668 | GNE-431 | ||
GNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM. GNE-431 showed excellent potency against the C481R, T474I, and T474M mutants. GNE-431 may provide a treatment option to patients, especia... | |||
T73276 | BTK-IN-23 | ||
BTK-IN-23 is a BTK inhibitor with an IC50 value of 12.8 nM, demonstrating kinase selectivity superior to Ibrutinib [1]. It also effectively inhibits BLX and BMX, with IC50 values of 35.6 nM and 5.7 nM, respectively. |