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N-piperidine Ibrutinib hydrochloride

Catalog No. T12152   CAS 2231747-18-3

N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor, a BTK ligand, inhibits WT BTK and C481S BTK, which can be used to synthesize a range of PROTAC molecules.N-piperidine Ibrutinib hydrochloride has potential anticancer N-piperidine Ibrutinib hydrochloride has potential anticancer activity, inhibiting the growth and proliferation of cancer cells.

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N-piperidine Ibrutinib hydrochloride Chemical Structure
N-piperidine Ibrutinib hydrochloride, CAS 2231747-18-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 48.00
5 mg In stock $ 113.00
10 mg In stock $ 183.00
25 mg In stock $ 352.00
50 mg In stock $ 523.00
100 mg In stock $ 757.00
1 mL * 10 mM (in DMSO) In stock $ 39.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor, a BTK ligand, inhibits WT BTK and C481S BTK, which can be used to synthesize a range of PROTAC molecules.N-piperidine Ibrutinib hydrochloride has potential anticancer N-piperidine Ibrutinib hydrochloride has potential anticancer activity, inhibiting the growth and proliferation of cancer cells.
Targets&IC50 BTK (WT):51.0 nM, BTK (C481S):30.7 nM
In vitro N-piperidine Ibrutinib hydrochloride can be used to synthesize effective PROTAC BTK degraders, such as SJF638, SJF678, and SJF608[2].
Molecular Weight 422.91
Formula C22H23ClN6O
CAS No. 2231747-18-3

Storage

keep away from direct sunlight

,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (189.16 mM), Sonification is recommeded

H2O: 30 mg/mL (70.94 mM), Sonification is recommeded

TargetMolReferences and Literature

1. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575. 2. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126877.

Related Products

Related compounds with same targets
GDC-0834 RN486 TAK-020 ARQ 531 BTK-IN-16 LFM-A13 Vecabrutinib PCI-33380

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Keywords

N-piperidine Ibrutinib hydrochloride 2231747-18-3 Angiogenesis Tyrosine Kinase/Adaptors BTK N-piperidine Ibrutinib Hydrochloride Npiperidine Ibrutinib hydrochloride N piperidine Ibrutinib hydrochloride inhibitor inhibit

 

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