irt1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9648	SIRT1-IN-1		Antiviral , Sirtuin
	SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM. SIRT1-IN-1 is an inhibitor of cytomegalovirus (CMV) with antiviral activity.		Antiviral , Sirtuin
T79565	Sirt1/2-IN-4		Sirtuin
	Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respectively. It effectively inhibits p53 deacetylation,...		Sirtuin
T23357	SIRT1/2 Inhibitor IV		Others
	SIRT1/2 Inhibitor IV (cannabinol) is a small-molecule inhibitor of SIRT1 and SIRT2 with IC50 values of 56 μM and 59 μM, respectively.		Others
T81154	SIRT1 activator 1		Sirtuin
	SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp. mangrove fungus, exhibits angiogenic effects in zebrafish and protects human endothelial progenitor cells (hEPCs) from AngI...		Sirtuin
T79563	Sirt1/2-IN-2		Sirtuin
	Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 a...		Sirtuin
T24792	SIRT1-I5	SIRT1-Inhibitor-I5,SIRT1 Inhibitor I5
	SIRT1-I5 is a SIRT1 inhibitor. It shows a potent effect on the prostate cancer cell line.
T62240	Sirt1/2-IN-1
	Sirt1/2-IN-1 (Compound 7) is an inhibitor of SIRT1 and SIRT2 and is capable of acting on SIRT1 (IC50: 1.81 μg/mL), SIRT2 (IC50: 2.10 μg/mL) and SIRT3 (IC50: 20.5 μg/mL) and has α-microtubulin hyperacetylation activity ( ...
T60631	SIRT1-IN-3
	SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC 50 of 4.2 μM [1].
T74894	SIRT1/2/3-IN-1
	SIRT1/2/3-IN-1 (compound 10) is a potent, selective, and cell-permeable inhibitor targeting SIRT1, SIRT2, and SIRT3, demonstrating inhibitory concentrations (IC50s) of 0.54 μM, 0.253 μM, and 0.72 μM, respectively. It is ...
T79564	Sirt1/2-IN-3		Sirtuin
	Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively. This compound effectively inhibits p53 deacetylation while simultaneously elev...		Sirtuin
T24791	SIRT1-A2	SIRT1-Activator-A2,SIRT1A2,SIRT1 Activator A2
	SIRT1-A2 is a SIRT1 activator.
T60373	SIRT1-IN-2
	SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1].

Compounds

SIRT1-IN-1

T9648

Synonym:

Target: Antiviral, Sirtuin

Synonym: SIRT1-Inhibitor-I5,SIRT1 Inhibitor I5

Synonym: SIRT1-Activator-A2,SIRT1A2,SIRT1 Activator A2

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03337	Iba1 Protein, Human, Recombinant (His)	Human	E. coli
	AIF1, also known as IBA1, is an actin-binding protein. AIF1 is expressed selectively in human macrophage-like cell lines, and in a subset of CD68(+) macrophages in the interstitial and perivascular spaces of human hear...
TMPY-02421	PARP3 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular resp...
TMPY-01869	SIRT1 Protein, Human, Recombinant (His)	Human	E. coli
	SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent prote...