Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIRT1/2 Inhibitor IV (cannabinol) is a small-molecule inhibitor of SIRT1 and SIRT2 with IC50 values of 56 μM and 59 μM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 114.00 | |
10 mg | Inquiry | $ 198.00 | |
25 mg | Inquiry | $ 416.00 | |
50 mg | Inquiry | $ 740.00 | |
100 mg | Inquiry | $ 1,232.00 |
Description | SIRT1/2 Inhibitor IV (cannabinol) is a small-molecule inhibitor of SIRT1 and SIRT2 with IC50 values of 56 μM and 59 μM, respectively. |
In vitro | SIRT1/2 Inhibitor IV is a cell-permeable SIRT1 and SIRT2 inhibitor. SIRT1/2 Inhibitor IV inhibited human SIRT1 and SIRT2 NAD-dependent deacetylase activity with IC50 values of 56 and 59 μmol/L, respectively. In the NCI H460 lung cancer cell line, combined inhibition of SIRT2 and HDAC6 with SIRT1/2 Inhibitor IV and trichostatin A resulted in hyperacetylation of tubulin. SIRT1/2 Inhibitor IV also increased acetylation of p53. In p53-positive lung cancer cell line NCI H460, SIRT1/2 Inhibitor IV mediated inhibition of SIRT1 sensitized cells to etoposide in a p53-independent manner [1]. |
In vivo | In a mouse xenograft model, SIRT1/2 Inhibitor IV (100 mg/kg) administered i.v. into the tail vein or i.p. daily for 2 weeks (five injections per week) reduced tumor growth [1]. In mice pre-treated with cannabinol for 2 hours and then exposed to 6% oxygen for 6 hours, cannabinol significantly reduced EPO mRNA in the kidney and the liver [2]. |
Molecular Weight | 360.43 |
Formula | C21H16N2O2S |
CAS No. | T23357 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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SIRT1/2 Inhibitor IV T23357 Others SIRT-1/2 Inhibitor IV inhibitor inhibit