irak4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11673	IRAK4-IN-4		IRAK , cGAS
	IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor, has an IC50 of 2.8 nM.		IRAK , cGAS
T4140	IRAK4-IN-1		IRAK
	IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.		IRAK
T62714	IRAK4-IN-20	BAY-1834845	IRAK
	IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS).		IRAK
T5354	IRAK4-IN-7	CA-4948	IRAK
	IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.		IRAK
T63388	IRAK4-IN-8		IRAK
	IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation.		IRAK
T39901	PROTAC IRAK4 degrader-4	PROTAC IRAK4 degrader-4
	PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T39902	PROTAC IRAK4 degrader-5	PROTAC IRAK4 degrader-5
	PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader.
T39920	PROTAC IRAK4 degrader-3	PROTAC IRAK4 degrader-3
	PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
T39903	PROTAC IRAK4 degrader-6	PROTAC IRAK4 degrader-6
	PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T24174	IRAK4-IN-16
	IRAK4-IN-16 (compound 4) is a potent inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with an IC 50 of 2.5 nM. IRAK4-IN-16 exhibits cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC...
T13843	PROTAC IRAK4 ligand-1		Others
	PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.		Others
T13842	PROTAC IRAK4 degrader-1		Others
	PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4).		Others
T11674	IRAK4-IN-6		Others
	IRAK4-IN-6 is a selective and orally efficacious inhibitor of IRAK4, demonstrating an IC50 value of 4 nM. This compound specifically targets MyD88 L265P mutant diffuse large B-cell lymphoma [1].		Others
T79485	IRAK4-IN-27		IRAK
	IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) c...		IRAK
T62950	IRAK4-IN-18
	IRAK4-IN-18 is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK4) (IC50: 15 nM). IRAK4-IN-18 inhibits LPS-induced IL23 production in THP and DC cells and blocks the development of arthritis in rats,...
T61767	IRAK4-IN-17
	IRAK4-IN-17 (Compound 5) is a highly potent inhibitor of IRAK4, exhibiting an impressive IC50 value of 1.3 nM [1]. This compound is particularly valuable for research focused on large B-cell lymphoma (DLBCL) [1].
T60899	IRAK4-IN-11
	IRAK4-IN-11 (compound 6) is a potent inhibitor of IRAK4 with an IC 50 of 0.008 μM. IRAK4-IN-11 exhibits cell pIRAK4 potencies with an IC 50 of 0.19 μM [1].
T62850	IRAK4-IN-13
	IRAK4-IN-13 (compound 21) is a selective and potent IRAK4 inhibitor (IC50: 0.6 nM). iRAK4-IN-13 has a high metabolic clearance, with an intrinsic human liver microsomal (HLM) clearance of 96 μL/min/mg.
T63558	IRAK4-IN-21
	IRAK4-IN-21 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 5 nM) and TAK1 (IC50: 56 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.17 μM. can be ...
T61734	IRAK4-IN-9
	IRAK4-IN-9 (compound 73) is a highly potent inhibitor of IRAK4, displaying an impressive IC50 value of 1.5 nM. By blocking MyD88-dependent signaling, IRAK4-IN-9 exhibits promising potential for the investigation of infla...