Search Result

Search Results for " il6 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T8468	CIL62		Caspase
	CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].		Caspase
T80564	Vamikibart
	Vamikibart is a chimeric, humanized IgG2κ antibody that targets IL6 [1].
T76826	Sirukumab
	Sirukumab (CNTO-136), a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody, holds potential for research in active lupus nephritis [1].
T63051	(R)-MALT1-IN-3
	(R)-MALT1-IN-3 (compound 121) is a potent inhibitor of MALT1 protease (IC50: 20 nM) with IC50 values of 60 nM and 40 nM for human IL6/IL10 in OCI-LY3 cells, respectively.
T41260	SC144 hydrochloride
	SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation...
T63053	MALT1-IN-3
	MALT1-IN-3 is a potent inhibitor of MALT1 protease (IC50: 0.06 μM) with IC50 values of 0.14 and 0.13 μM for human IL6 and IL10, respectively, in OCI-LY3 cells.
T8775	Lisuride maleate	R-(+)-LISURIDE HYDROGEN MALEATE
	Lisuride maleate is an agonist of Dopamine receptor and anti-Parkinson's agent. Displays high affinity for D2, D3 and D4 receptors along with 5-HT1A. Exhibits some 5-HT2B receptor antagonist properties. Decreases prolact...
T80847	W1131 TFA		STAT
	W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. Besides mitigating chemoresistance to 5-FU in canc...		STAT
T73558	W1131
	W1131, a potent STAT3 inhibitor, effectively triggers ferroptosis and suppresses cancer progression across various models including gastric cancer cell subcutaneous xenograft, organoids, and patient-derived xenograft (PD...
T83775	STING Agonist 12L	Stimulator of Interferon Genes Agonist 12L
	STING agonist 12L is a stimulator of interferon genes (STING) agonist that exhibits binding affinity for both wild-type STING and its variants R232, AQ, and Q with half-maximal inhibitory concentrations (IC50s) of 1.15 µ...

Compounds

Synonym: R-(+)-LISURIDE HYDROGEN MALEATE

Synonym: Stimulator of Interferon Genes Agonist 12L

Target:

Cat No.	Product Name	Synonyms	Targets
TN6739	Angoline	6-Methoxyldihydrochelerythrine	IL Receptor , STAT
	Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits can...		IL Receptor , STAT
T75672	Angoline hydrochloride
	Angoline hydrochloride, a selective inhibitor of the IL6/STAT3 signaling pathway, demonstrates potent activity with an IC50 value of 11.56 μM. It effectively inhibits STAT3 phosphorylation and the expression of its targe...

Natural Products

Angoline

TN6739

Synonym: 6-Methoxyldihydrochelerythrine

Target: IL Receptor, STAT

Angoline hydrochloride

T75672

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01067	CEBPD Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the express...
TMPK-00101	IL-6 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression.Interleukin 6 has been shown to interact with interleukin-6 recep...
TMPY-00863	IL-6 Protein, Human, Recombinant	Human	E. coli
	IL-6 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20.95 kDa and the accession number is P05231.
TMPY-01076	Gp130/IL6ST Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	gp130/IL6ST Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 96 kDa and the accession number is P40189-1.
TMPY-01832	Gp130/IL6ST Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	gp130/IL6ST Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is Q00560.
TMPY-06745	Gp130/IL6ST Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	gp130/IL6ST Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 94.11 kDa and the accession number is AAA59155.1.
TMPY-03743	Gp130/IL6ST Protein, Rhesus, Recombinant (His)	Rhesus	HEK293 Cells
	gp130/IL6ST Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.2 kDa and the accession number is A0A8J8YAN3.
TMPY-00387	Gp130/IL6ST Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	gp130/IL6ST Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 94.4 kDa and the accession number is AAA59155.1.
TMPY-01995	Gp130/IL6ST Protein, Rat, Recombinant (His & mFc)	Rat	HEK293 Cells
	gp130/IL6ST Protein, Rat, Recombinant (His & mFc) is expressed in HEK293 mammalian cells with His, mFc tag. The predicted molecular weight is 94.3 kDa and the accession number is H9BFG4.
TMPY-05793	Gp130/IL6ST Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	gp130/IL6ST Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 93.38 kDa and the accession number is Q00560.
TMPY-02148	Gp130/IL6ST Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	gp130/IL6ST Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68.2 kDa and the accession number is H9BFG4.
TMPY-03687	Gp130/IL6ST Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293 Cells
	gp130/IL6ST Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 102.6 kDa and the accession number is A0A8J8YAN3.
TMPK-00646	Gp130/IL6ST Protein, Rhesus macaque, Recombinant (His)	Rhesus	HEK293 Cells
	gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic fa...
TMPY-06039	Gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK)	Human	HEK293 Cells
	gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK) is expressed in HEK293 mammalian cells. The predicted molecular weight is 68.4 kDa and the accession number is P40189-1.
TMPK-00412	Gp130/IL6ST Protein, Human, Recombinant (His)	Human	HEK293 Cells
	gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic fa...
TMPJ-00291	IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated	Human	HEK293 Cells
	Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to...
TMPH-02156	SOCS1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through ...
TMPH-02738	IRAK3 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by ...
TMPJ-00397	IL-17RA Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	CD217, also known as Interleukin-17 receptor A, is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F, it binds to IL17A with higher affinity than to I...
TMPJ-00081	CNTF Protein, Human, Recombinant	Human	E. coli
	Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species ...
TMPJ-01003	STAT5B Protein, Human, Recombinant (His)	Human	E. coli
	Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth, survival, differ...
TMPY-02240	STAT1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate t...
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold fun...
TMPH-02841	Prohibitin Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regul...