il-33 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T76910	Astegolimab	RG 6149,MSTT 1041A	Interleukin
	Astegolimab (RG 6149) is a humanised IgG2 monoclonal antibody that targets the IL-33 receptor and inhibits IL-33 signalling. Astegolimab is used in the study of chronic obstructive pulmonary disease (COPD) and severe ast...		Interleukin
T77045	Itepekimab	REGN-3500,SAR-440340	Others
	Itepekimab (REGN-3500) is a potent monoclonal antibody against IL-33.Itepekimab reduces airway inflammation and associated tissue damage in in vivo experiments and can be used to study asthma.		Others
T76679	Etokimab
	Etokimab (Antibody ANB 020), a humanized monoclonal antibody, specifically targets IL-33. It is utilized in the research of atopic dermatitis [1].
T83741	S7 TFA	Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH
	S7, a peptide antagonist of the IL-6 receptor, concentration-dependently inhibits IL-6 binding to its receptor. At 50 µM, S7 suppresses IL-6-triggered elevations in VEGF levels within C-33 A cervical cancer cells and RPM...
T73149	HPK1-IN-33
	HPK1-IN-33 (compound 21), a Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor, exhibits a high potency with a K_i of 1.7 nM. It effectively inhibits IL-2 production, demonstrating EC_50 values of 286 nM in Jurkat WT cel...
T29542	AC708	AC 708,AC-708
	AC708 is a small molecule CSF1R inhibitor that effectively inhibits CSF1R phosphorylation mediated by CSF-1 (IC50 = 26 nM) and IL-34 (IC50 = 33 nM). It also inhibited the activity of growth factor-dependent cells culture...
T69671	SR1903 TFA
	SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated rec...
T35638	SR 1903
	SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It al...
T37052	Tetranactin
	Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold g...

Compounds

Astegolimab

T76910

Synonym: RG 6149,MSTT 1041A

Target: Interleukin

Itepekimab

T77045

Synonym: REGN-3500,SAR-440340

Synonym: Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH

Synonym: AC 708,AC-708

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01210	IL-33 Protein, Mouse, Recombinant	Mouse	E. coli
	Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identifi...
TMPY-05449	IL-33 Protein, Cynomolgus, Recombinant	Cynomolgus	E. coli
	IL-33 Protein, Cynomolgus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.1 kDa and the accession number is A0A2K5W3I1.
TMPY-02789	IL-33 Protein, Canine, Recombinant	Canine	E. coli
	IL-33 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.8 kDa and the accession number is O97863.
TMPY-00861	IL-33 Protein, Human, Recombinant	Human	E. coli
	IL-33 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is O95760-1.
TMPJ-00617	IL-33 Protein, Rhesus macaque, Recombinant (His)	Rhesus	E. coli
	Interleukin-33 (IL-33) belongs to the IL-1 superfamily. IL33 is highly expressed in endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes, but almost undetectable in placenta. IL33 induces the pr...
TMPK-00163	IL-33 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are exp...
TMPH-03115	IL-33 Protein, Pig, Recombinant (GST)	Sus scrofa (Pig)	E. coli
	N/A. IL-33 Protein, Pig, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 44.6 kDa and the accession number is M5B263.
TMPK-00405	IL-17RA Protein, Human, Recombinant (aa 33-320, hFc & Avi), Biotinylated	Human	HEK293 Cells
	Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restr...
TMPK-01029	IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His)	Mouse	HEK293 Cells
	Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disea...
TMPK-01202	CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated	Human	HEK293 Cells
	CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperrespons...
TMPJ-01361	Siglec-8 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory mo...