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Search Results for " idh2 "

10

Compounds

Cat No. Product Name Synonyms Targets
T6820 D-α-Hydroxyglutaric acid disodium D-alpha-Hydroxyglutaric acid disodium salt,Disodium (R)-2-Hydroxyglutarate ATPase , Others , Reactive Oxygen Species , Endogenous Metabolite , mTOR
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.
T79745 IDH2R140Q-IN-2 Dehydrogenase
IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation ...
T63193 IDH2R140Q-IN-1
IDH2R140Q-IN-1 is a potent inhibitor of IDH2R140Q (IC50: 6.1 nM) and can be used in studies of acute myeloid leukemia.
T2346 Enasidenib AG-221 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Enasidenib (AG-221) is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity.
T1809 AGI-6780 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
T2346L Enasidenib mesylate AG221 mesylate,AG 221 mesylate,AG-221 mesylate Dehydrogenase
Enasidenib mesylate (AG-221 mesylate) is a potent and selective IDH2 mutase inhibitor that promotes differentiation of leukemia myeloid cells for the treatment of acute myeloid leukemia.
T7307 Vorasidenib PVM/MA,AG-881 Isocitrate Dehydrogenase (IDH)
Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)
T39716 Mutant IDH1-IN-6 Mutant IDH1-IN-6
Mutant IDH1-IN-6 is an orally active compound that effectively inhibits mutant isocitrate dehydrogenase (IDH) enzymes. It demonstrates potency and selectivity, with IC50 values of 6.27, 3.71, 36.9, and 11.5 nM for IDH1 R...
T63402 (S,R)-WT IDH1 Inhibitor 2
(S,R)-WT IDH1 Inhibitor 2 is a selective and potent mutant IDH1 inhibitor that inhibits R132G (IC50: 2.9 nM), R132C (IC50: 3.8 nM), R132H (IC50: 4.6 nM) and WT IDH1 (IC50: 46 nM) with 100-fold higher selectivity than IDH...
T78758 IHMT-IDH1-053 Isocitrate Dehydrogenase (IDH)
IHMT-IDH1-053 (compound 16) is an irreversible inhibitor exhibiting high selectivity for the IDH1 R132H mutant, achieving an IC50 of 4.7 nM. It preferentially targets IDH1 mutants over wild-type IDH1 and IDH2, both wild-...
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