hsp90α — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T79323	PROTAC Hsp90α degrader 1		HSP
	Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research. It demonstrates inhibitory effects on the proliferation of breast cancer cell line...		HSP
T8958	PU-H54		GPR
	PU-H54 is a purine-based inhibitor of Grp94. It is a Grp94-selective resorcinol-based inhibitor isolated through probing of the exclusive binding region of S2 subpocket in Grp94.		GPR
T6609	NMS-E973		HSP
	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.		HSP
T16994	Pimitespib	TAS-116	HSP
	Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).		HSP
T6118	NVP-HSP990	HSP990	Apoptosis , HSP
	NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).		Apoptosis , HSP
T1989	Luminespib	AUY922,VER-52296,NVP-AUY922	Apoptosis , HSP , Autophagy
	Luminespib (VER-52296) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).		Apoptosis , HSP , Autophagy
T7261	Grp94 Inhibitor-1		GPR , HSP
	Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).		GPR , HSP
T6558	KW-2478	KW2478	HSP
	KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.		HSP
T24685	PU-20F
	PU-20F is a selective inhibitor of Hsp90α and Hsp90 .
T15088	Debio 0932	CUDC-305	HSP
	Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).		HSP
T78809	NDNA3		HSP
	NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A cells, with IC50 values of 12.66 μM and 11.72 μM respectively. ...		HSP
T78808	NDNA4		HSP
	NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability. It exhibits minimal cytotoxicity against Ovcar-8 and MCF-10A cell lines (IC50 >100...		HSP
T69365	HMS607P03
	HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP...
T64261	HDAC/HSP90-IN-4
	HDAC/HSP90-IN-4 significantly inhibited HDAC and HSP90 activity, with compound 20 (HDACIC50= 194 nM; HSP90αIC50= 153 nM) and compound 26 ((HDACIC50= 360 nM; HSP90αIC50= 77 nM) having the strongest HDAC and HSP90α inhibit...
T79486	MAO A/HSP90-IN-1		Monoamine Oxidase
	MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α. This compound impairs the activities of MAO A, disrupts HSP90...		Monoamine Oxidase
T63528	HSP90-IN-11
	HSP90-IN-11 is a potent inhibitor of HSP90 and induces significant accumulation of the sub-G1 population. HSP90-IN-11 has a potent HSP90α inhibitory effect comparable to that of AUY-922 (Luminespib). In CRC and NSCLC cel...