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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3624 | A-366 | A 366,A366 | Epigenetic Reader Domain , Histone Methyltransferase |
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met... | |||
T15648 | KDM5-C70 | Histone Demethylase | |
KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide e... | |||
T39989L | JQKD82 trihydrochloride | Histone Demethylase | |
JQKD82 trihydrochloride, a cell-permeable and selective inhibitor of KDM5, enhances H3K4me3 levels and is utilized in multiple myeloma research. | |||
T3552 | CPI-455 | CPI-455 HCl | Histone Demethylase |
CPI-455 is a specific KDM5 inhibitor. | |||
T15650 | KDM5A-IN-1 | Histone Demethylase | |
KDM5A-IN-1 is an orally available, potent and selective inhibitor of the pan-histidine lysine demethylase 5 KDM5, inhibiting KDM5A, KDM5B, and KDM5C with IC50 values of 45 nM, 56 nM, and 55 nM, respectively.KDM5A-IN-1 in... | |||
T8768 | MM-102 TFA | HMTase Inhibitor IX TFA | Histone Methyltransferase |
MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM. MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WD... | |||
T7057 | Methylstat | Histone Demethylase , Others | |
Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD... | |||
T15649 | KDM5-IN-1 | Histone Demethylase | |
KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM. | |||
T39989 | JQKD82 | JADA82,PCK82,JQKD82 | Histone Demethylase |
JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma. | |||
T62729 | MS31 trihydrochloride | ||
MS31 trihydrochloride is a selective, high-affinity, fragment-like inhibitor of the methyl-lysine read-write protein spindlin 1 (SPIN1). MS31 trihydrochloride effectively disrupts the interaction of SPIN1 with H3K4me3 pr... | |||
T22299 | CPI-455 HCl | Histone Demethylase | |
CPI-455 is a specific KDM5 inhibitor with IC50 value of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer c... | |||
T60354 | KDM4-IN-4 | ||
KDM4-IN-4 (compound 47) is a potent inhibitor of histone lysine demethylase 4 (KDM4), demonstrating modest affinity with a binding constant of approximately 80 μM for the KDM4A-Tudor domain. It effectively inhibits the b... | |||
T72388 | CBB1007 hydrochloride | ||
CBB1007 HCl is a cell-permeable amidino-guanidinium compound identified as a potent, reversible, and substrate-competitive inhibitor of LSD1 (IC50 = 5.27 μM for hLSD1). It effectively inhibits LSD1-mediated demethylation... | |||
T72244 | CBB1007 trihydrochloride | ||
CBB1007 trihydrochloride is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1). IC50 Value: 5.27 uM ... |