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CPI-455

Catalog No. T3552 CAS 1628208-23-0

Synonyms: CPI-455 HCl

CPI-455 is a specific KDM5 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CPI-455, CAS 1628208-23-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 37.00
2 mg	In stock	$ 50.00
5 mg	In stock	$ 79.00
10 mg	In stock	$ 133.00
25 mg	In stock	$ 298.00
50 mg	In stock	$ 475.00
100 mg	In stock	$ 678.00
500 mg	In stock	$ 1,380.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.02%

Purity: 97.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CPI-455 is a specific KDM5 inhibitor.
Targets&IC50	KDM5A:10 nM (IC50)
In vitro	CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1]. CPI-455 has a high measured affinity for the target KDM5 proteins. Within 24 hours, CPI-455 and CPI-766 can dose-dependently increases in H3K4me3, but not H3K4me2. IC50 calculation for KDM5 Inhibitor CPI-455 in 3 luminal breast cancer cell lines MCF-7, T-47 and EFM-19 are 35.4, 26.19 and 16.13 μM, respectively.
Cell Research	All cell lines were treated with DMSO, CPI-4203 or CPI-455 for 5 d with two changes of medium and drug. Thereafter, the cells (PC9, Colo205, Hs888, M14, SKBR3 and EVSA-T) were plated at 2×105 cells in six-well plates in triplicate and treated for an additional 9-15 d, depending on the cell line model. The Incucyte HD imaging system was used to monitor numbers of drug-tolerant cells after cells were stained with Nuclear-ID Red stain. (Only for Reference)

Synonyms	CPI-455 HCl
Molecular Weight	278.31
Formula	C16H14N4O
CAS No.	1628208-23-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 5.63 mg/mL (20.21 mM)

References and Literature

1. Vinogradova M, et al. Nat Chem Biol. 2016, 12(7):531-8. 2. Li S T, Huang D, Shen S, et al. Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis[J]. Nature Metabolism. 2020, 2(3): 256-269.

Citations

1. Li S T, Huang D, Shen S, et al. Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis. Nature Metabolism. 2020, 2(3): 256-269 2. Shen X, Ye Z, Wu W, et al. lncRNA NEAT1 facilitates the progression of colorectal cancer via the KDM5A/Cul4A and Wnt signaling pathway. International Journal of Oncology. 2021, 59(1): 1-12.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Highly Selective Inhibitor Library Inhibitor Library Histone Modification Compound Library Anti-Cancer Compound Library Epigenetics Compound Library Bioactive Compound Library Bioactive Compounds Library Max Stem Cell Differentiation Compound Library Anti-Aging Compound Library

Related Products

Related compounds with same targets

KDM4C-IN-1 DDP-38003 dihydrochloride CPI-455 HCl KDM4D-IN-1 KDM5-C70 Kgp-IN-1 RN-1 dihydrochloride KDM2A/7A-IN-1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CPI-455 1628208-23-0 Chromatin/Epigenetic Histone Demethylase CPI-455 HCl CPI455 CPI 455 Inhibitor inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.