16
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7261 | Grp94 Inhibitor-1 | GPR , HSP | |
Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM). | |||
T70088 | Grp94-IN-2 | ||
Grp94-IN-2 is a inhibitor of Grp94. | |||
T70087 | EPZ032597 | Histone Methyltransferase | |
EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and can be used to prevent and treat pancreatic cancer. | |||
T8958 | PU-H54 | GPR | |
PU-H54 is a purine-based inhibitor of Grp94. It is a Grp94-selective resorcinol-based inhibitor isolated through probing of the exclusive binding region of S2 subpocket in Grp94. | |||
T30480 | BiP inducer X | BIX | Apoptosis |
BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines. | |||
T2114 | VER-82576 | NVP-BEP800 | HSP |
VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94. | |||
T5351L | PU-WS13 hydrobromide | PU-WS13 hydrobromide (1454619-14-7 Free base) | GPR |
PU-WS13 hydrobromide is a GRP94 inhibitor with anti-inflammatory activity and inhibits the proliferation of M2-like macrophages in mouse TNBC tumors. | |||
T6118 | NVP-HSP990 | HSP990 | Apoptosis , HSP |
NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM). | |||
T24704 | Radamide | ||
Radamide is an inhibitor of Grp94. | |||
T20890 | Alvespimycin | 17-DMAG,KOS1022,KOS 1022,KOS-1022 | HSP |
Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90. | |||
T27755 | KUNG38 | KUNG-38,KUNG 38 | |
KUNG38 is a purine-based inhibitor of Grp94. | |||
T24687 | PU-H54-iso | PU H54-iso,PUH54-iso | |
PU-H54-iso is a novel Hsp90- and Grp94-selective inhibitor. | |||
T27756 | KUNG94 | KUNG 94,KUNG-94 | |
KUNG94 is a potent and selective inhibitor of Glucose regulated protein 94 (Grp94) (IC50 = 8 nM), the endoplasmic reticulum resident of the 90 kDa heat shock protein (Hsp90) family. | |||
T79285 | TRAP1-IN-1 | HSP | |
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90. It exhibits over 250-fold greater selectivity for TRAP1 compared to Grp94, destabilizes TRAP1 tetramers, and p... | |||
T12726 | Retaspimycin | Others | |
Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9). | |||
T12726L | Retaspimycin Hydrochloride | IPI-504 | Others |
Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM). |