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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8552 | PSEM 89S TFA | AChR | |
PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively. | |||
T4811 | D-Alanine | D-α-Alanine,Ba 2776,(R)-Alanine,(R)-2-Aminopropionic acid | Chloride channel , Endogenous Metabolite |
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. D-Alanine ((R)-Alanine) is a weak GlyR (inhibitory... | |||
T78025 | LQVTDSGLYRCVIYHPP | ||
LQVTDSGLYRCVIYHPP (LP17) is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that mitigates ischemia-induced infarction and neuronal damage. It can penetrate the brain and inhibit TREM-1 [1]. | |||
T11434 | GlyRS-IN-1 | Others | |
GlyRS-IN-1 is an inhibitor of glycyl-tRNA synthase (GlyRS). It can inhibit the growth of bacteria. | |||
T78026 | LQVTDSGLYRCVIYHPP TFA | ||
LQVTDSGLYRCVIYHPP (LP17) TFA is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that notably mitigates ischemic infarction and neuronal damage. This compound is capable of penetrating the bra... | |||
T16533 | Picrotin | Chloride channel | |
Picrotin is an inhibitor of glycine receptors. Picrotin blocks α2 GlyR, α1 GlyR, and α3 GlyR and can be used in studies about neurotransmission. | |||
T36810 | UPSEM 792 hydrochloride | ||
Ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-f... | |||
T36811 | UPSEM 817 tartrate | ||
Selective ultrapotent PSEM (uPSEM) agonist for α7L131G,Q139L,Y217F-GlyR (PSAM4-GlyR) and PSAM4-5-HT3 chimeric ion channel agonist (EC50 values are 0.3 and 0.5 nM, respectively). Suppresses firing of layer 2/3 cortical ... | |||
T10618 | Broflanilide | GABA Receptor | |
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR (IC50: 1.3 nM). | |||
T61655 | AM-1488 | ||
AM1488 is a potent, orally active glycine receptor ( GlyR ) potentiator (hGlyRα3 EC 50 =0.45 μM) [1] [2]. | |||
T16292 | NFPS | Thrombin | |
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM a... | |||
T37391 | PSEM 308 hydrochloride | ||
PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neuro... |