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Search Results for " glyr "

12

Compounds

Cat No. Product Name Synonyms Targets
T8552 PSEM 89S TFA AChR
PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively.
T4811 D-Alanine D-α-Alanine,Ba 2776,(R)-Alanine,(R)-2-Aminopropionic acid Chloride channel , Endogenous Metabolite
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. D-Alanine ((R)-Alanine) is a weak GlyR (inhibitory...
T78025 LQVTDSGLYRCVIYHPP
LQVTDSGLYRCVIYHPP (LP17) is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that mitigates ischemia-induced infarction and neuronal damage. It can penetrate the brain and inhibit TREM-1 [1].
T11434 GlyRS-IN-1 Others
GlyRS-IN-1 is an inhibitor of glycyl-tRNA synthase (GlyRS). It can inhibit the growth of bacteria.
T78026 LQVTDSGLYRCVIYHPP TFA
LQVTDSGLYRCVIYHPP (LP17) TFA is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that notably mitigates ischemic infarction and neuronal damage. This compound is capable of penetrating the bra...
T16533 Picrotin Chloride channel
Picrotin is an inhibitor of glycine receptors. Picrotin blocks α2 GlyR, α1 GlyR, and α3 GlyR and can be used in studies about neurotransmission.
T36810 UPSEM 792 hydrochloride
Ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-f...
T36811 UPSEM 817 tartrate
Selective ultrapotent PSEM (uPSEM) agonist for α7L131G,Q139L,Y217F-GlyR (PSAM4-GlyR) and PSAM4-5-HT3 chimeric ion channel agonist (EC50 values are 0.3 and 0.5 nM, respectively). Suppresses firing of layer 2/3 cortical ...
T10618 Broflanilide GABA Receptor
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR (IC50: 1.3 nM).
T61655 AM-1488
AM1488 is a potent, orally active glycine receptor ( GlyR ) potentiator (hGlyRα3 EC 50 =0.45 μM) [1] [2].
T16292 NFPS Thrombin
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM a...
T37391 PSEM 308 hydrochloride
PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neuro...
TargetMol