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Search Results for " gpvi "

9

Compounds

2

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T61811 GPVI antagonist 3
GPVI antagonist 3 (Compound 2) is a potential antagonist that shows promising antiplatelet activity by selectively inhibiting the interaction between the Glycoprotein VI (GPVI) receptor and its ligands. It demonstrates p...
T62250 GPVI antagonist 2
GPVI antagonist 2 (Compound 1) is a potential Glycoprotein VI (GPVI) antagonist, able to act on collagen (IC50: 0.35 μM), CRP (IC50: 0.80 μM), convulxin (IC50: 195.2 μM), thrombin (IC50. 81.38 μM). GPVI antagonist 2 is a...
T61697 GPVI antagonist 1
GPVI antagonist 1 (compound 5) functions as an antagonist for the glycoprotein VI (GPVI) platelet receptor. It effectively inhibits collagen-induced platelet aggregation, demonstrating an IC50 value of 25.3 μM [1].
T0948 Adrenalone hydrochloride Adrenalone HCl Adrenergic Receptor
Adrenalone hydrochloride (Adrenalone HCl) is a dopamine β-oxidase inhibitor with a similar structure to the norepinephrine transporter (NET) ligand, with an IC50 of 36.9 μM. It is an adrenergic agonist that acts as a loc...
T28281 OXSI-2 OXSI 2,Syk Inhibitor Syk
OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.
T77442 Glenzocimab ACT017 Others
Glenzocimab (ACT017) is a Fab fragment of a humanized anti-GPVI monoclonal antibody. Glenzocimab demonstrated inhibition of collagen-induced platelet aggregation in an ischemic stroke model. Glenzocimab has been studied ...
T11824LL Lanraplenib GS-9876 Syk
Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI ...
T11824 Lanraplenib succinate GS-9876 succinate Syk
Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib succinate is a highly selective and orally active S...
T11824L Lanraplenib monosuccinate GS-9876 monosuccinate Syk
Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib monosuccinate is a highly selective and orally...
Cat No. Product Name Synonyms Targets
TN3460 Asebogenin Antifungal
Asebogenin is a compound fractionated from Salvia miltiorrhiza with antifungal activity, inhibition of GPVI-induced platelet reactions, and inhibition of NET formation induced by pro-inflammatory stimuli.
T4S0498 Glaucocalyxin A Wangzaozin B,Leukamenin F Apoptosis , Akt , Caspase , PI3K
1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-01302 GPVI Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycopro...
TMPK-01190 GPVI Protein, Human, Recombinant (His) Human HEK293 Cells
Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycopro...
TMPJ-00605 GPVI Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregat...
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