Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 47.00 | |
2 mg | In stock | $ 68.00 | |
5 mg | In stock | $ 101.00 | |
10 mg | In stock | $ 170.00 | |
25 mg | In stock | $ 306.00 | |
50 mg | In stock | $ 453.00 | |
100 mg | In stock | $ 667.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 117.00 |
Description | Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. |
Targets&IC50 | Syk:9.5 nM |
In vitro | Lanraplenib (GS-9876) inhibits glycoprotein VI (GPVI)-induced phosphorylation of linker for activation of T cells and phospholipase Cγ2, platelet activation and aggregation in human whole blood, and platelet binding to collagen under arterial flow [2]. Lanraplenib inhibits anti-IgM stimulated phosphorylation of AKT, BLNK, BTK, ERK, MEK, and PKCδ in human B cells (EC50s: 24-51 nM). Lanraplenib inhibits anti-IgM mediated CD69 and CD86 expression on B-cells (EC50: 112±10 nM and 164±15 nM, respectively) and anti-IgM /anti-CD40 co-stimulated B cell proliferation (EC50: 108±55 nM). In human macrophages, Lanraplenib inhibits IC-stimulated TNFα and IL-1β release (EC50: 121±77 nM and 9±17 nM, respectively) [1]. |
Synonyms | GS-9876 |
Molecular Weight | 443.5 |
Formula | C23H25N9O |
CAS No. | 1800046-95-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 41.67 mg/mL (93.96 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Lanraplenib 1800046-95-0 Angiogenesis Tyrosine Kinase/Adaptors Syk Spleen tyrosine kinase Inhibitor GS9876 GS-9876 GS 9876 inhibit inhibitor