exatecan — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11249	Exatecan	DX-8951,DX-8951f	Topoisomerase
	Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).Exatecan has antitumor activity and may be used in cancer research.		Topoisomerase
T40159	(4-NH2)-Exatecan		Topoisomerase
	(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).		Topoisomerase
TQ0088	Exatecan Mesylate	DX8951f	Topoisomerase
	Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).		Topoisomerase
T11249L	Dxd	Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ	Topoisomerase
	Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC.		Topoisomerase
T77847	MC-Val-Cit-PAB-Exatecan	MC-Val-Cit-PAB-DX8951
	MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) is a conjugate of the DNA topoisomerase I inhibitor DX-8951 and a cathepsin-cleavable antibody-drug conjugate (ADC) linker, designed for targeted cancer therapy application...
T77901	Ac-Exatecan		Topoisomerase
	Ac-Exatecan, the acetylated form of Exatecan (DX-8951), serves as a prevalent cytotoxic agent in antibody-drug conjugate (ADC) formulations (ADC Cytotoxin) and acts as an inhibitor of DNA topoisomerase I with an IC50 val...		Topoisomerase
T63624	Exatecan-amide-cyclopropanol
	Exatecan-amide-cyclopropanol is an anticancer agent that inhibits the proliferation of SK-BR-3 cells (IC50: 0.12 nM) and U87 cells (IC50: 0.23 nM).
T74735	Gly-Cyclopropane-Exatecan
	Gly-Cyclopropane-Exatecan, a DNA Topoisomerase I inhibitor containing Exatecan, is key in synthesizing the anti-B7-H4 ADC, specifically the ADC hu2F7-Exatecan (compound 34). This compound demonstrated antitumor activity ...
T83577	(1-OH)-Exatecan
	(1-OH)-Exatecan, a quinoline ring compound, exhibits substantial antiproliferative effects and is utilized in research for cancer diseases [1].
T78630	Exatecan mesylate dihydrate	DX-8951 mesylate dihydrate	Topoisomerase
	Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].		Topoisomerase
T77849	Val-Ala-PABC-Exatecan
	Val-Ala-PABC-Exatecan is a Drug-Linker Conjugate for Antibody-Drug Conjugate (ADC) synthesis, comprising a cleavable Tesirine linker (Val-Ala-PABC) and the topoisomerase I inhibitor Exatecan. It is utilized in the constr...
T67020	Exatecan Intermediate 1
	Exatecan Intermediate 1 is a useful organic compound for research related to life sciences. The catalog number is T67020 and the CAS number is 110351-94-5.
T83513	(αR)-Cyclopropaneacetamide-Exatecan
	(αR)-Cyclopropaneacetamide-Exatecan (compound 2-A), an Exenotecan derivative, serves as a cytotoxic agent that effectively inhibits the proliferation of U87MG and SK-BR-3 cells, exhibiting IC50 values of 8.11 and 2.31 μM...
T77854	MC-VA-PAB-Exatecan
	MC-VA-PAB-Exatecan is an agent-linker conjugate designed for Antibody-Drug Conjugate (ADC) applications, comprising the ADC linker (peptide MC-VA-PAB) and the DNA topoisomerase I inhibitor Exatecan. Synthesis of this con...
T77889	NH2-methylpropanamide-Exatecan TFA		Topoisomerase
	Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.975 μg/mL), utilized in the synthesis of ADCs for cancer res...		Topoisomerase
T77886	GGFG-amide-glycol-amide-Exatecan
	Exatecan (Intermediate 2), a derivative of GGFG-amide-glycol-amide-Exatecan, facilitates the synthesis of antibody-drug conjugates (ADCs) [1].
T81872	Mal-PEG8-Phe-Lys-PAB-Exatecan
	Compound 15, Mal-PEG8-Phe-Lys-PAB-Exatecan, is an antibody-drug conjugate (ADC) comprised of the degradable linker Mal-PEG8-Phe-Lys-PAB and the cytotoxic agent Exatecan [1].
T77855	Mal-PEG8-Val-Ala-PAB-Exatecan
	Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b), an antibody-drug conjugate linker (ADC linker), binds Nectin-4 polypeptides to chemotherapeutic agents for use in cancer research [1].
T77888	Mal-PEG2-Gly-Gly-Phe-Gly-Exatecan
	Mal-PEG2-Gly-Gly-Phe-Gly-Exatecan is a drug-linker conjugate for antibody-drug conjugates (ADCs), comprising Exatecan tethered by a maleimidopropyl (Mal) PEGylated tetrapeptide linker. It is utilized for the synthesis of...
T77867	Mal-PEG8-Phe-Lys-PAB-Exatecan TFA
	Mal-PEG8-Phe-Lys-PAB-Exatecan TFA is a conjugate for ADC comprised of the degradable linker Mal-PEG8-Phe-Lys-PAB and the cytotoxic agent Exatecan [1].