egfr-in-7 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11161	EGFR-IN-7	TQB3804	EGFR
	EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.		EGFR
T61272	EGFR/HER2-IN-7
	EGFR/HER2-IN-7 is a highly selective and potent anticancer compound specifically designed to target MCF-7 breast cancer cells. It functions as a dual inhibitor, targeting both EGFR/HER2 kinases and DHFR (dihydrofolate re...
T77746	Tyrosine kinase-IN-7		EGFR , Antiviral
	Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity in a variety of cancer cell lines. Tyrosine kinase-IN-7 has pote...		EGFR , Antiviral
T11163	EGFR-IN-9		EGFR
	EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity.		EGFR
T4S0544	Furanodienone		Apoptosis , HER
	1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in BT474 and SKBR3 cells, the effect is specifically dependen...		Apoptosis , HER
T60574	EGFR-IN-53
	EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].
T62446	EGFR-IN-63
	EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).
T79651	EGFR-IN-83		EGFR
	EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects on MCF-7 and MDA-MB-231 cell lines, with respective IC50 values of 2.50 μM and 1.96 μM. Furthermore, EGFR-IN-83 is ca...		EGFR
T79727	EGFR/CDK2-IN-2		EGFR
	EGFR/CDK2-IN-2 (compound 6a) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 19.6 nM and 87.9 nM, respectively. It promotes apoptosis in MCF-7 cells and halts cell cycle progression du...		EGFR
T79729	EGFR/CDK2-IN-4		EGFR
	EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, demonstrating IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2. It prompts apoptosis in MCF-7 cells and causes S phase cell cycle arrest, e...		EGFR
T63810	BTK-IN-7
	BTK-IN-7 is a selective and potent BTK inhibitor with an IC50 value of 4.0 nM. BTK-IN-7 exhibits high selectivity at both the enzymatic (ITK>250-fold, EGFR>2500-fold) and cellular levels (ITK>227-fold, EGFR27-fold). BTK-...
T62503	EGFR/BRAFV600E-IN-1
	EGFR/BRAFV600E-IN-1 (Compound 23) is a potent dual inhibitor of EGFR (IC50: 0.08 μM) and BRAFV600E (IC50: 0.15 μM). EGFR/BRAFV600E-IN-1 exhibited anti-proliferative effects on A-549 (IC50: 1.2 μM), MCF-7 (IC50: 0.79 μM),...
T74623	PROTAC EGFR degrader 7
	PROTAC EGFR degrader 7 (compound 13b) is a potent, selective CRBN-recruiting agent targeting EGFR L858R/T790M mutations with a DC50 of 13.2 nM. It effectively inhibits proliferation in NCI–H1975 cells with an IC50 of 46....
T79728	EGFR/CDK2-IN-3		EGFR
	EGFR/CDK2-IN-3 (compound 4b) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 71.7 nM and 113.7 nM, respectively. It prompts apoptosis in MCF-7 cells and halts the cell cycle in the S p...		EGFR
T79327	EGFR-IN-81		EGFR
	EGFR-IN-81 (Compound 10i), an EGFR inhibitor, demonstrates potent activity by inhibiting EGFR WT and the L858R/T790M mutation at IC50 values of 4.38 nM and 5.69 nM, respectively. It also exhibits cytotoxic effects agains...		EGFR
T61596	EGFR/HER2/DHFR-IN-1
	EGFR/HER2/DHFR-IN-1 is a highly selective and potent anticancer compound specifically targeting MCF-7 breast cancer cells. It acts as a multi-inhibitor, targeting the EGFR/HER2 kinase and DHFR enzymes, with IC50 values o...
T63205	HSP90-IN-13
	HSP90-IN-13 (compound 5k) is a potent broad-spectrum inhibitor of HSP90 with an IC50 of 25.07 nM. HSP90-IN-13 has multitargeted activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 blocks the MCF-7 cell cycle ...
T63492	BI-1622
	BI-1622 is a highly selective, orally active HER2(ERBB2) inhibitor (IC50: 7 nM). BI-1622 is >25-fold selective for EGFR. In a mouse model of transplanted tumors transfected with H2170 and PC9 cells, BI-1622 exhibited hig...
T35423	7-oxo Staurosporine
	7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respe...
T81739	Multi-target kinase inhibitor 2		EGFR
	Compound 5K (Multi-target kinase inhibitor 2) is a multi-targeted kinase inhibitor demonstrating activity against EGFR, Her2, VEGFR2, and CDK2 with IC50 values between 40 to 204 nM. It exhibits cytotoxic effects on HepG2...		EGFR