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Search Results for " cyp17 "

Targets

11

Compounds

1

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T10923 CYP17-IN-1 P450
CYP17-IN-1 is an effective oral inhibitor of CYP17 that can inhibit CYP17 in rats and humans with IC50 of 15.8 and 20.1 nM.
T13312L Seviteronel VT-464 P450 , Androgen Receptor
Seviteronel (VT-464) is a novel CYP17 cleavage enzyme inhibitor and androgen receptor antagonist for the study of breast and prostate cancer.
T6216 Abiraterone CB-7598 P450
Abiraterone (CB-7598) (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50: 4 nM).
T6509 Galeterone VN-124-1,TOK-001,VN/124-1,VN 124 P450 , Androgen Receptor
Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an a...
T30161 EN3356 AS N001,ASN-001 P450
EN3356 is an orally available and selective inhibitor of steroidal 17-alpha-hydroxylase/C17,20 cleavage enzyme (CYP17A1 or CYP17), a non-steroidal cleavage enzyme-selective compound with potential anti-androgenic and ant...
T6215 Abiraterone Acetate Zytiga,CB7630 P450
Abiraterone Acetate (CB7630) is an androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER.
T13313 Seviteronel racemate VT-464 (racemate) Others
Seviteronel racemate is the racemate form of Seviteronel and is a potent inhibitor of CYP17 lyase.
T63434 Abiraterone decanoate
Abiraterone decanoate is a prodrug of Abiraterone that provides controlled release and long-lasting CYP17 inhibition of Abiraterone using intramuscular (IM) delivery.
T71102 CFG920
CFG920 is a CYP17 inhibitor, is also an orally available inhibitor of the steroid 17-alpha-hydroxylase/C17,20 lyase (CYP17A1 or CYP17), with potential antiandrogen and antineoplastic activities. Upon oral administration,...
T13312 Seviteronel R enantiomer VT-464 (R enantiomer) Others
Seviteronel R enantiomer is the R enantiomer of Seviteronel and is a potent inhibitor of CYP17 lyase (IC50: 69 nM for h-Lyase).
T6051 Orteronel TAK-700,(S)-Orteronel P450
Orteronel ((S)-Orteronel)(TAK-700) was selected as a candidate for clinical evaluation. orteronel (TAK-700) is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer.
Cat No. Product Name Synonyms Targets
T0603 Phthalic acid mono-2-ethylhexyl ester Phthalic Acid Monooctyl Ester P450 , Endogenous Metabolite
Phthalic acid mono-2-ethylhexyl ester (Phthalic Acid Monooctyl Ester is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17. Cyp17a1 gene is a specific target ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-02139 CYP17A1 Protein, Human, Recombinant (GST) Human E. coli
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen sy...
TMPH-02143 NR5A1 Protein, Human, Recombinant (His) Human E. coli
Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B an...
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