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Seviteronel racemate

Catalog No. T13313 CAS 1375603-36-3

Synonyms: VT-464 (racemate)

Seviteronel racemate is the racemate form of Seviteronel and is a potent inhibitor of CYP17 lyase.

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Seviteronel racemate, CAS 1375603-36-3

Pack Size	Availability	Price/USD
2 mg	6-8 weeks	$ 198.00
5 mg	6-8 weeks	$ 347.00
25 mg	6-8 weeks	$ 1,140.00
50 mg	6-8 weeks	$ 1,490.00
100 mg	6-8 weeks	$ 1,990.00
1 mL * 10 mM (in DMSO)	6-8 weeks	$ 382.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Seviteronel racemate is the racemate form of Seviteronel and is a potent inhibitor of CYP17 lyase.
Targets&IC50	CYP17 Lyase (human):69 nM
In vivo	The MDA-PCa-133 xenograft, originating from a clinical castration-resistant prostate cancer (CRPC) bone metastasis, exhibits expression of PSA, the full-length androgen receptor (AR), and the AR-V7 isoform subcutaneously. In a study involving castrated male mice bearing the MDA-PCa-133 tumor, subjects were divided into three groups and underwent 25 days of oral treatment with either a vehicle, Seviteronel (VT-464) at 100 mg/kg twice daily, or Abiraterone Acetate (AA) at 100 mg/kg twice daily. Results demonstrated that both Seviteronel (VT-464) and AA significantly reduced tumor volume by more than two-fold relative to the vehicle group (p<0.05). The study highlights that Seviteronel’s (VT-464) selective CYP17 lyase inhibition is comparably effective to AA’s CYP17 inhibition in reducing tumor volume in this model [2].

Synonyms	VT-464 (racemate)
Molecular Weight	399.34
Formula	C18H17F4N3O3
CAS No.	1375603-36-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (125.21 mM), Sonication is recommended.

References and Literature

1. Rafferty SW, et al. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7. 2. Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models. Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Seviteronel racemate 1375603-36-3 Others VT-464 (racemate) VT-464 VT464 racemate VT 464 inhibitor inhibit

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