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Search Results for " cpt-11 "

8

Compounds

Cat No. Product Name Synonyms Targets
T6228 Irinotecan CPT-11,Topotecin,(+)-Irinotecan Topoisomerase , Autophagy
Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting...
T0486L Irinotecan Hydrochloride Camptothecin 11 hydrochloride,CPT-11 hydrochloride Topoisomerase , Autophagy
Irinotecan Hydrochloride (CPT-11 hydrochloride) is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptoth...
T0486 Irinotecan hydrochloride trihydrate Irinotecan HCl Trihydrate,CPT-11 HCl Trihydrate Topoisomerase , Autophagy
Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.
T19553 RPR132595A NPC Others
RPR132595A is an active CPT-11 metabolite, it is generated by cytochrome P-450 3A4 (CYP3A4).
T78069 RPR132595A hydrochloride NPC hydrochloride Drug Metabolite
RPR132595A (NPC) hydrochloride, an active metabolite of CPT-11, is produced via cytochrome P-450 3A4 (CYP3A4) metabolism and is ultimately eliminated via urinary excretion [1].
T38474 CL2-MMT-SN38 CL2-MMT-SN38
CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.
T70380 ZBH-1205
ZBH-1205 is a novel camptothecin derivative, revealing potent antitumor activities mainly through cell apoptosis pathway, being more effective than cpt-11 and sn38 at inhibiting topoismerase-1
T78711 A011 ATM/ATR
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumo...
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