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Search Result

Search Results for " clax "

Targets

BCL Ligands for Target Protein for PROTAC

19

Compounds

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T12186 Navitoclax-piperazine ABT-263-piperazine BCL , Ligands for Target Protein for PROTAC
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).
T6650 Sabutoclax BI-97C1 BCL
Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
T11944 Maritoclax Marinopyrrole A BCL
Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value of 10.1 μM.
T39910 Desmorpholinyl Navitoclax-NH-Me Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me BCL
Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2].
T6275 Obatoclax Mesylate Obatoclax,GX15-070 BCL , Parasite , Autophagy
Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.
T10483 Lisaftoclax Bcl-2/Bcl-xl inhibitor 1,APG-2575 BCL
Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL...
T2101 Navitoclax ABT-263 BCL
Navitoclax (ABT-263) is a Bcl-2 inhibitor that binds to Bcl-xL, Bcl-2, and Bcl-w proteins (Ki<1 nM) with potent and oral activity. Navitoclax has antitumor activity and induces apoptosis.
T2119 Venetoclax GDC-0199,ABT 199,ABT-199,ABT199 BCL , Autophagy
Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48/245 nM). Venetoclax induces a...
T71456 Navitoclax dihydrochloride
Navitoclax dihydrochloride is a synthetic small-molecule antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity.
T74637 Sonrotoclax
Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].
T16694 Pyridoclax MR-29072 BCL
Pyridoclax is an inhibitor of potential Mcl-1.
T41278 Obatoclax
Obatoclax (GX15-070), a pan-BCL-2 family proteins inhibitor and BH3 mimetic, exhibits a binding affinity (K_i) of 220 nM for BCL-2. It promotes autophagy-dependent cell death and cyclin D1 degradation via the proteasome....
T79852 Lacutoclax
Lacutoclax, a Bcl-2 inhibitor, exhibits antineoplastic activity [1].
T78638 Clezutoclax
Clezutoclax, a potent Bcl-XL inhibitor, serves as an effective payload for the synthesis of antibody-drug conjugates (ADCs) [1].
T22257 Murizatoclax Others
AMG 397 is an oral MCL1 inhibitor .
T36901 Pelcitoclax
Pelcitoclax (APG-1252) is a powerful inhibitor of the Bcl-2 and Bcl-xl proteins, displaying significant antineoplastic and pro-apoptotic properties[1].
T14213 Tapotoclax AMG-176 BCL
AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).
T74015 Venetoclax N-oxide
Venetoclax N-oxide is an impurity of Venetoclax. Venetoclax (ABT-199; GDC-0199), a highly potent, selective, and orally bioavailable inhibitor of Bcl-2, demonstrates a Ki value of less than 0.01 nM [1].
T27600 Imlatoclax
Imlatoclax has antineoplastic activity.

Recombinant Proteins

Species：
Human (2)
Expression System：
HEK293 Cells (2)
Tag：
N-hFc-Avi (2)
Cat No. Product Name Species Expression System
TMPK-01231 CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293 Cells
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclamps...
TMPK-01230 CLEC2D Protein, Human, Recombinant (hFc & Avi) Human HEK293 Cells
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclamps...
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