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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $999 | 7-10 days |
Description | AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM). |
In vitro | AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (Ki=0.13 nM). It has potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. Which disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells[1][2]. |
Alias | AMG-176 |
Molecular Weight | 613.21 |
Formula | C33H41ClN2O5S |
Cas No. | 1883727-34-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 62.5 mg/mL (101.92 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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