Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | Inquiry | |
50 mg | 10-14 weeks | Inquiry | |
100 mg | 10-14 weeks | Inquiry |
Description | AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM). |
Targets&IC50 | MCL1:0.13 nM (ki) |
In vitro | AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (Ki=0.13 nM). It has potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. Which disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells[1][2]. |
Synonyms | AMG-176 |
Molecular Weight | 613.21 |
Formula | C33H41ClN2O5S |
CAS No. | 1883727-34-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (101.92 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Tapotoclax 1883727-34-1 Apoptosis BCL AMG 176 AMG-176 AMG176 inhibitor inhibit