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Tapotoclax

Catalog No. T14213   CAS 1883727-34-1
Synonyms: AMG-176

AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).

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Tapotoclax Chemical Structure
Tapotoclax, CAS 1883727-34-1
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).
Targets&IC50 MCL-1:0.13 nM (ki)
In vitro AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (Ki=0.13 nM). It has potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. Which disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells[1][2].
Synonyms AMG-176
Molecular Weight 613.21
Formula C33H41ClN2O5S
CAS No. 1883727-34-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62.5 mg/mL (101.92 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 Sep 25. pii: CD-18-0387. 2. Garner TP, et al. Progress in targeting the BCL-2 family of proteins. Curr Opin Chem Biol. 2017 Aug;39:133-142.

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Keywords

Tapotoclax 1883727-34-1 Apoptosis BCL AMG 176 AMG-176 AMG176 inhibitor inhibit

 

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