cftr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2355	CFTR(inh)-172	CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172	CFTR , Autophagy
	CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.		CFTR , Autophagy
T10776	CFTR corrector 4		CFTR
	CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface a...		CFTR
T5312	CFTR corrector 2	FDL169	CFTR , Autophagy
	CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.		CFTR , Autophagy
T63806	CFTR corrector 8		CFTR
	CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic...		CFTR
T60653	CFTR corrector 9		CFTR
	CFTR Corrector 9, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, is employed in the research of cystic fibrosis (CF) and related CFTR-associated disorders [1].		CFTR
T1874	PPQ-102	PPQ102,CFTR Inhibitor,PPQ 102	CFTR , Autophagy
	PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).		CFTR , Autophagy
T37686	CFTR corrector 6
	CFTR corrector 6 is a highly effective CFTR potentiator utilized in research on cystic fibrosis (CF) and related CFTR-associated disorders[1]. This potent compound exhibits potentiation activity on the Cystic Fibrosis Tr...
T79578	CFTR corrector 12		CFTR
	CFTR Corrector 12 (Compound 17C), a bithiazole derivative, functions as a CFTR corrector by remedying certain folding-defective mutants of the channel that regulates chloride transport across the plasma membrane. Additio...		CFTR
T2451	GlyH-101	GlyH 101	CFTR , Autophagy
	GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.		CFTR , Autophagy
T3135	KM11060		CFTR , Autophagy
	KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane.		CFTR , Autophagy
T1805	Ataluren	PTC124	CFTR , Autophagy
	Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and olde...		CFTR , Autophagy
T9499	Icenticaftor	QBW251	CFTR
	Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.		CFTR
T14935	Elexacaftor	VX-445	CFTR , Autophagy
	Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.		CFTR , Autophagy
T16681	Nesolicaftor	PTI-428	CFTR , Autophagy
	Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.		CFTR , Autophagy
T2S1837	Steviol	NSC 226902,Hydroxydehydrostevic acid	Others
	1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif...		Others
T2588	Ivacaftor	Ivacaftor (VX-770),VX-770	CFTR , Autophagy
	Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.		CFTR , Autophagy
T10591	BPO-27 racemate	BPO-27 (racemate)	CFTR , Autophagy
	BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.		CFTR , Autophagy
T2486	IOWH-032	IOWH032,IOWH 032	CFTR , Autophagy
	IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.		CFTR , Autophagy
T7083	GLPG1837	ABBV-974	CFTR , Autophagy
	GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.		CFTR , Autophagy
T2595	Lumacaftor	VX-809,VRT 826809	CFTR , Autophagy
	Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).		CFTR , Autophagy