Search Result

Search Results for " cd73 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T10721	CD73-IN-1		CD73
	CD73-IN-1 is a CD73 inhibitor with anticancer activity.		CD73
T9210	CD73-IN-4		CD73
	CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor		CD73
T8875	CD73-IN-3	EX-A4254,LY-3475070	CD73
	CD73-IN-3 (LY-3475070) is a potent and selective CD73 inhibitor with an IC50 of 28 nM, and its use alone or in combination with pembrolizumab is currently being tested in patients with advanced cancer.		CD73
T40033	CD73-IN-5	CD73-IN-5
	CD73-IN-5 is a highly potent and selective small molecule inhibitor of CD73, demonstrating non-nucleotide characteristics. It exerts its inhibitory effects with a remarkable IC50 value of 19 nM.
T61118	CD73-IN-12
	CD73-IN-12 is a highly effective CD73 inhibitor that displays strong potential in tumor suppression. CD73, an enzyme intricately linked to tumor development, angiogenesis, and metastasis, is significantly inhibited by CD...
T60779	CD73-IN-13
	CD73-IN-13 is able to be used in a medicament preparing for tumor-related diseases. CD73-IN-13 is a potent inhibitor of CD73 which is closely associated with tumor growth, angiogenesis and metastasis [1].
T61053	CD73-IN-11
	CD73-IN-11 is able to used for tumor-related diseases medicament preparing. CD73-IN-11 is an effective CD73 inhibitor. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP) whic...
T63128	CD73-IN-2
	CD73-IN-2 is a potent inhibitor of CD73 (IC50: 0.09 nM).
T61691	CD73-IN-6
	CD73-IN-6, serves as a potent inhibitor of CD73. This compound finds utility in cancer research [1].
T61090	CD73-IN-8
	CD73-IN-8, a potent CD73 inhibitor, prevents the catalytic activity of CD73, an enzyme responsible for converting extracellular 5'-phosphate adenosine (5'-AMP) to adenosine. Adenosine, once produced, can induce immunosup...
T61000	CD73-IN-10
	CD73-IN-10 can be used in preparing tumor-related diseases medicament. CD73-IN-10 is a potent CD73 inhibitor that can catalyze the adenosine production from extracellular 5'-phosphate adenosine (5'-AMP). Adenosine induce...
T60844	CD73-IN-9
	CD73-IN-9 is a potent CD73 inhibitor that be used in preparing the tumor-related diseases medicament. CD73 can catalyze the adenosine production from extracellular 5'-phosphate adenosine (5'-AMP). The adenosine can induc...
T60599	CD73-IN-7
	CD73-IN-7 is a potent CD73 inhibitor that can be used for preparing a medicament for tumor-related diseases. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP) which can indu...
T10216	AB-680		CD73
	AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.		CD73
T76735	Mupadolimab	CPI-006	CD73
	Mupadolimab (CPI-006) is a humanized FC-γR binding deficient IgG1 anti-CD73 antibody with potential anticancer activity and activation of CD73POS B cells.		CD73
T12569L	PSB-12379 ditriethylamine salt		CD73
	PSB-12379 ditriethylamine salt, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).		CD73
T22392	OP-5244		Others
	OP-5244 has comparable potency to bisphosphonic acid series and targets CD73.		Others
T12007	MethADP sodium salt		Others
	MethADP is a specific CD73 inhibitor.		Others
T12569	PSB-12379		Others
	PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).		Others
T12008	MethADP	Adenosine 5'-(α,β-methylene)diphosphate	Others
	MethADP is a specific inhibitor of CD73.		Others
T71538	AMPCP
	AMPCP is an Ecto-5'-nucleotidase (CD73) inhibitor.
T77155	Dalutrafusp alfa
	Dalutrafusp alfa (AGEN-1423; GS-1423) is a bifunctional antibody targeting CD73 and TGF-β, components of the immunosuppressive pathway [1].
T76695	Oleclumab
	Oleclumab (MEDI9447), a human IgG1λ monoclonal antibody, targets and inhibits CD73 functionality, demonstrating anti-tumor activity [1].
T22411	PSB-12489		Others
	PSB-12489 is an optimized inhibitor of CD73.		Others
T76214	5′-Nucleotidase
	5′-Nucleotidase (CD73), an ectoenzyme and intrinsic membrane glycoprotein, catalyzes the hydrolysis of 5-nucleotides into their corresponding nucleosides [1].
T80603	Dresbuxelimab	AK-119	CD73
	Dresbuxelimab (AK-119), an IgG-κ monoclonal antibody, selectively targets CD73 and is commonly produced using a Chinese Hamster Ovary (CHO) cell expression system [1].		CD73
T64019	ZM514
	ZM514 is a potent inhibitor of CD73, acting on hCD73 (IC50: 1.39 μM) and mCD73 (IC50: 14.65 μM). zM514 has low cytotoxicity and can be used in anti-cancer studies.
T73628	PSB-12379 disodium
	PSB-12379 disodium is a nucleotide analogue acting as a potent inhibitor of Ecto-5'-Nucleotidase (CD73), demonstrating inhibitory constants (Ki) of 9.03 nM in rats and 2.21 nM in humans [1] [2].
T63956	OP-5244 sodium
	OP-5244 sodium is a potent, orally active inhibitor of CD73 (IC50: 0.25 nM). OP-5244 sodium has shown potential for cancer research by blocking adenosine production and thereby reversing immunosuppression.
T76730	Uliledlimab
	Uliledlimab, a humanized monoclonal antibody, exhibits potent activity against CD73, inhibiting the conversion of extracellular adenosine monophosphate (AMP) to adenosine. It holds potential for use in cancer research [1...
T73886	AB-680 ammonium
	AB-680 ammonium is a potent, reversible, and selective CD73 inhibitor (an ecto-nucleotidase), demonstrating a K i of 4.9 pM against hCD73 and exhibiting more than 10,000-fold selectivity over the related ecto-nucleotidas...
T74865	BK50164
	BK50164, a potent CD73 inhibitor, exhibits an IC50 of 13.089 µM and demonstrates affinity for CD99 with a KD value of 1.5 µM. This compound not only possesses antiproliferative activity but also induces apoptosis and cel...
T35573	Adenosine 5’-methylenediphosphate (hydrate)
	Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or ...

Compounds

Synonym: EX-A4254,LY-3475070

PSB-12379 ditriethylamine salt

Synonym: Adenosine 5'-(α,β-methylene)diphosphate

Adenosine 5’-methylenediphosphate (hydrate)

T35573

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01342	CD73 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-03540	CD73 Protein, Rat, Recombinant (His)	Rat	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-03377	CD73 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-01851	CD73 Protein, Human, Recombinant (His)	Human	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-05580	CD73 Protein, Human, Recombinant (hFc)	Human	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-05454	CD73 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-06907	CD73 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...