Search Result

Search Results for " caix "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T36758	CAIX Inhibitor S4	S4	Carbonic Anhydrase
	CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.		Carbonic Anhydrase
T2017	U-104	NSC-213841,MST-104	Carbonic Anhydrase
	U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).		Carbonic Anhydrase
T60745	HCAIX-IN-5		Carbonic Anhydrase
	hCAIX-IN-5 was a selective hCAIX inhibitor, inhibiting hCAI, hCAII, hCAIV, and hCAIX with Ki values of >10000, >10000, 130.7, and 829.1 nM, respectively.		Carbonic Anhydrase
T61384	HCAIX/XII-IN-4
	hCAIX/XII-IN-4 (compound 6c) is a highly potent inhibitor of CAIX/XII. It exhibits Ki values of 4.5 nM, 23.6 nM, >10000 nM, and >10000 nM for CAXII, CAIX, CAI, and CAⅡ, respectively [1].
T61873	HCAIX/XII-IN-1
	hCAIX/XII-IN-1, a potent inhibitor of both CAIX and CAXII, exhibits KI values of 0.48 μM for CAIX and 0.83 μM for CAXII, respectively. This compound demonstrates antiproliferative activity in vitro and induces apoptosis ...
T74955	HCAIX-IN-13
	hCAIX-IN-13 (Pt2), a Carbonic Anhydrase IX (CAIX) inhibitor, demonstrates a notable IC50 value of 6.57 μM, efficiently impeding cancer cell growth and promoting apoptosis. It is valuable for cancer research [1].
T61896	HCAIX-IN-12
	hCAIX-IN-12 is an effective hCAIX inhibitor, IC50 for CAIX and CAII is 0.74 and 10.78 μM , respectively. hCAIX-IN-12 inhibits cell proliferation and induces apoptosis. HCAIX-IN-12 can increase the generation of ROS. HCAI...
T61852	HCAIX-IN-8
	hCAIX-IN-8 (compound 7i) is a highly potent and selective inhibitor of hCAIX, demonstrating potent inhibitory activity against CAIX with an IC50 value of 0.024 μM. It also exhibits inhibitory activity against CAII and CA...
T62026	HCAIX-IN-11
	hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor. hCAIX-IN-11 shows K i s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively.
T60602	HCAIX/XII-IN-5
	hCAIX/XII-IN-5 (Coumarin 9a) is an inhibitor of carbonic anhydrase (CA) that shows excellent hCA IX/XII selectivity with Kis of 93.3 and 85.7 nM over hCA I and hCA II, respectively. hCAIX/XII-IN-5 has anti-proliferative ...
T74486	HCAIX-IN-17
	Compound 6f, also known as hCA IX-IN-1, is a human carbonic anhydrase (hCA) inhibitor that exhibits varying inhibitory effectiveness across different hCA isoforms, with K i values of 331.4 nM for hCA I, 28.4 nM for hCA I...
T73029	HCAIX-IN-15		Carbonic Anhydrase
	hCAIX-IN-15 is a potent inhibitor of human carbonic anhydrase IX (hCA IX) with an inhibition constant (Ki) of 38.8 nM, exhibiting broad-spectrum anticancer activity suitable for cancer research [1].		Carbonic Anhydrase
T78729	HCAIX/VII-IN-1		Carbonic Anhydrase
	hCAIX/VII-IN-1 is a selective inhibitor of human carbonic anhydrase isoforms VII and IX. It displays inhibitory activity against hCA I, II, IV, VII, and IX, with respective K_i values of 336.2 nM, 185.8 nM, 1055 nM, 35.6...		Carbonic Anhydrase
T79748	HCAIX/XII-IN-7		Carbonic Anhydrase
	Compound 3e (hCAIX/XII-IN-7) is a potent inhibitor of human carbonic anhydrase (hCA) isozymes IX and XII, displaying inhibitory constants (Kis) of 503.7 nM for hCA IX and 59 nM for hCA XII, while also showing activity ag...		Carbonic Anhydrase
T73028	HCAIX-IN-16		Carbonic Anhydrase
	hCAIX-IN-16 (Compound 12d), an inhibitor of hCA IX, exhibits inhibition constants (K i) of 190.0 nM for hCA IX and 187.9 nM for hCA XII. It can arrest the cell cycle in the G0-G1 and S phases and induce apoptosis in MDA-...		Carbonic Anhydrase
T73030	HCAIX-IN-14
	hCAIX-IN-14 is a potent inhibitor of human CA IX with a K i value of 134.8 nM .
T63753	HCAIX-IN-3
	hCAII-IN-3 (compound 7e) is a selective and potent carbonic anhydrase (CA II/IX) inhibitors with their Kis values of 124.2 and 30.5 nM, respectively. hCAII-IN-1 has shown investigational potential for cancer disease.
T82234	HCAIX-IN-19
	hCAIX-IN-19 is a sulfonamide inhibitor with an inhibition constant (KI) of 6.2 nM for hCAIX, exhibiting significant selectivity towards hCAIX over hCAI (hCA I/hCAIX = 117).
T62755	HCAIX-IN-2
	HCAIX-IN-2 (compound 9d) is a selective inhibitor of carbonic anhydrase and acts on hCA IX (Ki: 24.6 nM) and hCA XII (Ki: 45.3 nM).
T61959	HCAIX/XII-IN-3
	hCAIX/XII-IN-3 (compound 6q) is a potent, selective inhibitor of hCAIX and hCAXII. hCAIX/XII-IN-3 shows K i values of >10000, >10000, 66.2, 4.4 nM for hCAI, hCAII, hCAIX and hCAXII, respectively .
T61237	HCAIX-IN-6
	Compounds 6B and 14g showed significant inhibitory effect on tumor related subtype HCA IX with low nanomolar potency, while 6K was effective on HCA XII. Compounds 6B, 14g and 6K can be considered as the leading molecules...
T72840	HCAIX/XII-IN-6
	hCAIX/XII-IN-6, an orally active carbonic anhydrase (CA) inhibitor, targets human CA isoforms hCA I, II, IV, IX, and XII with inhibition constants (K i) of 6697 nM, 2950 nM, 4093 nM, 4.1 nM, and 7.7 nM, respectively. Thi...
T79753	HCAIX/XII-IN-8		Carbonic Anhydrase
	hCAIX/XII-IN-8 (compound 3g) is a potent inhibitor of the human carbonic anhydrases (CAs) IX and XII, with inhibition constants (K i) of 8.5 nM for CA IX and 6.7 nM for CA XII. It demonstrates significant inhibitory effi...		Carbonic Anhydrase
T63158	HCAIX-IN-10
	hCAIX-IN-10 (Compound 6i) is a selective inhibitor of carbonic anhydrase IX and XII, acting on hCA IX (Ki: 61.5 nM) and hCA XII (Ki: 586.8 nM). hCA IX and hCA XII are transmembrane isoforms of carbonic anhydrase that act...
T60746	HCAIX-IN-7
	hCAIX-IN-7 (compound 6c) is a potent and selective inhibitor of hCAIX which is the tumor associated isoforms. hCAIX-IN-7 inhibits hCAI, hCAII, hCAIV, hCAIX with KIs of >10000, >10000, 43.0, 410.6 nM, respectively [1].
T61015	HCAIX/XII-IN-2
	hCAIX/XII-IN-2 (compound 6a) is a potent and selective inhibitor of hCAIX and hCAXII. The Ki values of hCAIX/XII-IN-2 for hCAI, hCAII, hCAIX and hCAXII are >10000, >10000, 30.0, 3.6 nM, respectively [1].
T76684	Girentuximab	cG250,WX-G250,G250	Carbonic Anhydrase
	Girentuximab (G250) is a potent anti-carbonic anhydrase IX (CAIX) monoclonal antibody with anticancer activity for the study of uroepithelial carcinoma PET (ZiPUP).		Carbonic Anhydrase
T70821	FC11409B
	FC11409B is a CAIX inhibitor, inhibiting breast cancer invasion and metastasis.
T71877	GC-204
	GC-204 is a selective inhibitor of carbonic anhydrase ix (caix)
T70813	DTP348
	DTP348 is an oral dual CAIX inhibitor/ radiosensitizer. DTP 348 is an oral dual drug with two mechanisms of action: (1). carbonic anhydrase IX inhibitor which acidifies the intracellular pH through the sulfamide componen...
TP2046	TAT-cyclo-CLLFVY
	Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expressi...
T36059	Dichlorphenamide-13C6	Dichlorphenamide-13C6
	Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor ...

Compounds

CAIX Inhibitor S4

T36758

Synonym: S4

Target: Carbonic Anhydrase

U-104

T2017

Synonym: NSC-213841,MST-104

Target: Carbonic Anhydrase

hCAIX-IN-5

T60745

Synonym:

Target: Carbonic Anhydrase

Target: Carbonic Anhydrase

hCAIX/VII-IN-1

T78729

Synonym:

Target: Carbonic Anhydrase

hCAIX/XII-IN-7

T79748

Synonym:

Target: Carbonic Anhydrase

hCAIX-IN-16

T73028

Synonym:

Target: Carbonic Anhydrase

Target: Carbonic Anhydrase

Synonym: cG250,WX-G250,G250

Target: Carbonic Anhydrase

Dichlorphenamide-13C6

T36059

Synonym: Dichlorphenamide-13C6

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00690	Carbonic Anhydrase 9 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Carbonic Anhydrase 9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.5 kDa and the accession number is A0A0S2Z3D0.
TMPY-00689	Carbonic Anhydrase 9 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Carbonic Anhydrase 9 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 67.7 kDa and the accession number is A0A0S2Z3D0.
TMPY-06936	Carbonic Anhydrase 9 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Carbonic Anhydrase 9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 44.23 kDa and the accession number is NP_001207.2.
TMPY-06939	Carbonic Anhydrase 9 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293 Cells
	Carbonic Anhydrase 9 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 69.51 kDa and the accession number is NP_001207.2.
TMPK-00524	CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tu...
TMPK-00283	CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tu...