c5ar — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T64200	C5aR-IN-2
	C5aR-IN-2 is a potent inhibitor of C5aR. C5aR-IN-2 has shown potential for the study of inflammatory diseases.
T73262	C5aR-IN-3
	C5aR-IN-3, a potent C5aR inhibitor, holds potential for inflammation disease research due to its ability to counteract increased C5a levels, which are linked to autoimmune and inflammatory disorders.
T73261	C5aR-IN-1
	C5aR-IN-1, a potent inhibitor of C5aR, is linked with the potential to research inflammatory diseases. This association is due to the elevated levels of C5a, which are connected with autoimmune and inflammatory disorders...
T82797	C5aR1 antagonist peptide
	C5aR1 antagonist peptide, a biologically active linear peptide originating from the C-terminus of the chemokine complement fragment 5 anaphylatoxin (C5a), inhibits C5a binding and activity at human and rat C5a receptors....
T12506L1	PMX 205 acetate(514814-49-4 free base)		Complement System
	PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).		Complement System
T8223	Avacopan	CCX168	Complement System
	Avacopan (CCX168) is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a murine model o...		Complement System
TP2334	PMX 53 acetate(219639-75-5 free base)		Complement System
	PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an ag...		Complement System
TP1305L	LEP(116-130)(mouse)TFA(258276-95-8 free base)		Complement System
	LEP(116-130)(mouse) is a synthetic leptin peptide fragment.		Complement System
T24524	NDT 9513727	NDT9513727,NDT-9513727	Complement System
	NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.		Complement System
T73710	PMX 205 Trifluoroacetate
	PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist.
T28429	PMX-53	PMX53,PMX 53
	PMX-53 is a Mas-related gene 2 (MrgX2) agonist and C5aR(CD88) antagonist. PMX-53 reduces atherosclerotic lesions in a mouse model of atherosclerosis, inhibits lung metastasis in a mouse breast cancer model, inhibits C5a-...
T35836	PMX-205 (trifluoroacetate salt)
	PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3...
T17250	W-54011		ROS , Complement System
	W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and g...		ROS , Complement System

Compounds

C5aR-IN-2

T64200

C5aR1 antagonist peptide

T82797

Synonym:

Target:

PMX 205 acetate(514814-49-4 free base)

T12506L1

Synonym:

Target: Complement System

Avacopan

T8223

Synonym: CCX168

Target: Complement System

PMX 53 acetate(219639-75-5 free base)

TP2334

Synonym:

Target: Complement System

LEP(116-130)(mouse)TFA(258276-95-8 free base)

TP1305L

Synonym:

Target: Complement System

NDT 9513727

T24524

Synonym: NDT9513727,NDT-9513727

Target: Complement System

PMX 205 Trifluoroacetate

Synonym: PMX53,PMX 53

Target:

PMX-205 (trifluoroacetate salt)

Target: ROS, Complement System

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01022	C5AR1 Protein-VLP, Human, Recombinant (His)	Human	HEK293 Cells
	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transm...
TMPH-01023	C5AR1 Protein, Human, Recombinant (Cell-Free, His)	Human	E. coli
	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transm...
TMPH-03529	Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His)	Staphylococcus aureus	P. pastoris (Yeast)
	Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leu...
TMPH-03528	Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc)	Staphylococcus aureus	E. coli
	Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leu...