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NDT 9513727

Catalog No. T24524 CAS 439571-48-9

Synonyms: NDT9513727, NDT-9513727

NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NDT 9513727, CAS 439571-48-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 137.00
5 mg	In stock	$ 335.00
10 mg	In stock	$ 538.00
25 mg	In stock	$ 855.00
50 mg	In stock	$ 1,150.00
100 mg	In stock	$ 1,550.00

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Purity: 99.21%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.
Targets&IC50	C5aR (human):11.6 nM
In vitro	NDT 9513727 inhibited C5a-stimulated responses, including guanosine 5′-3-O-(thio)triphosphate binding, Ca2+ mobilization, oxidative burst, degranulation, cell surface CD11b expression and chemotaxis in various cell types with IC50s from 1.1 to 9.2 nM, respectively[1].
In vivo	NDT 9513727 (3-30 mg/kg) effectively inhibited C5a-induced neutropenia in gerbil and cynomolgus macaque in vivo[1].

Synonyms	NDT9513727, NDT-9513727
Molecular Weight	573.68
Formula	C36H35N3O4
CAS No.	439571-48-9

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 30 mg/mL (52.26 mM)

DMSO: 80 mg/mL (139.37 mM), Sonication is recommended.

References and Literature

1. Robbin M Brodbeck, et al. Identification and characterization of NDT 9513727 [N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist. J Pharmacol Exp Ther. 2008 Dec;327(3):898-909. 2. Brodbeck RM, Cortright DN, Kieltyka AP, Yu J, Baltazar CO, Buck ME, Meade R, Maynard GD, Thurkauf A, Chien DS, Hutchison AJ, Krause JE. Identification and characterization of NDT 9513727 [N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanam ine], a novel, orally bioavailable C5a receptor inverse agonist. J Pharmacol Exp Ther. 2008 Dec;327(3):898-909. doi: 10.1124/jpet.108.141572. Epub 2008 Aug 27. PubMed PMID: 18753409.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NDT 9513727 439571-48-9 Immunology/Inflammation Complement System NDT9513727 NDT-9513727 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.