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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2586 | Cabozantinib | XL184,BMS-907351 | Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit |
Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity... | |||
T5164 | Cabozantinib hydrochloride | XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351 | VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR |
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM). | |||
T1797 | Cabozantinib S-malate | Cabozantinib,XL184,Cabozantinib Malate | Apoptosis , VEGFR , c-Met/HGFR , TAM Receptor , c-Kit |
Cabozantinib S-malate (XL184) is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. |