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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10354 | APX-115 | Ewha-18278 | NADPH-oxidase |
APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury. | |||
T10353 | APX-115 free base | Ewha-18278 free base | NADPH-oxidase , NADPH |
APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kid... | |||
T61355 | APX2039 | APX-2039,APX 2039 | Antifungal |
APX2039 is an orally active fungal Gwt1 enzyme inhibitor and a prodrug of the novel Gwt2096 inhibitor APX1.APX2039 exhibits potent anti-Kryptococcal activity against C. neoformans and C. gattii.APX2039 exhibits potent an... | |||
T23749 | APX001 | APX 001,APX-001 | |
APX001 is a prodrug of APX-001A. APX001 is the first-in-class inhibitor of the fungal protein Gwt1. | |||
T70731 | Odalasvir | ||
Odalasvir is a novel NS5A inhibitor for the treatment of hepatitis C. | |||
T70730 | Oxycodegol phosphate | ||
Oxycodegol phosphate is a mu-opioid agonist used in the treatment of Moderate to Severe Chronic Low Back Pain | |||
T70733 | APX2009 | ||
APX2009 is a second-generation APE1/Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell prolifer... | |||
T70732 | APX2014 | ||
APX2014 is a novel potent and specific Ref-1 inhibitor, blocking in vitro cell proliferation and activating apoptosis via PARP cleavage. | |||
T6823 | E3330 | HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis | |
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. | |||
T11314 | Fosmanogepix | APX001,E1211 | Others |
Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02433 | APE1/APEX1 Protein, Human, Recombinant (His) | Human | E. coli |
The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease, DNA 3' repair diest... | |||
TMPJ-00464 | APE Protein, Human, Recombinant | Human | E. coli |
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete re... | |||
TMPH-00096 | APX2, cytosolic Protein, Arabidopsis thaliana, Recombinant (His) | Arabidopsis thaliana | E. coli |
APX2, cytosolic Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.5 kDa and the accession number is Q1PER6. |