15
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T50098 | TIQ-A | PARP | |
TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m... | |||
T4022 | QS11 | QS 11 | GTPase |
QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also r... | |||
T15588 | Iobenguane sulfate | MIBG sulfate | Others |
Iobenguane sulfate (MIBG sulfate) is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation). Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmac... | |||
T15639 | K-756 | PARP , Wnt/beta-catenin | |
K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 and TNKS2 (IC50s: 31 and 36 nM, respectively). | |||
T67844 | RBN-3143 | PARP | |
RBN-3143 is a potent and inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM). RBN-3143 inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines. RBN-3143 exhibits research potential of lun... | |||
T31945 | Glutamyl ribose 5-phosphate | Glu-R-S-P | |
Glutamyl ribose 5-phosphate is obtained by the linkage region in ADP ribosylation of proteins. | |||
T78408 | Nicotinamide 1,N6-ethenoadenine dinucleotide | ε-NAD | |
Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD), a fluorescent NAD analogue, functions as a substrate in bacterial toxin-catalyzed G-ADP ribosylation of G-proteins involved in signal transduction. It is also applica... | |||
T68528 | M-COPA | ||
M-COPA is a golgi disruptor which inhibits cell surface expression of MET protein and the ADP-ribosylation factor 1 (Arf1) activation. M-COPA also inhibits angiogenesis through suppression of both VEGFR1/2 and nuclear fa... | |||
T27013 | CHS-111 | CHS 111 | |
CHS-111 is a benzyl indazole compound. CHS-111 inhibits superoxide anion (O(2)(-)) generation. CHS-111 reduces the fMLP-stimulated PLD activity (IC(50) 3.9±1.2μM). CHS-111 inhibits the interaction of PLD1 with ADP-ribosy... | |||
T71026 | MC2050 HCl | ||
MC2050 is a potent PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide trea... | |||
T21803 | Guanylyl Imidodiphosphate | ||
Guanylyl Imidodiphosphate trisodium (Guanosine 5'-[β,γ-imido]triphosphate), a non-hydrolysable GTP analogue, activates ADP-ribosylation factor (ARF) and strongly stimulates adenylate cyclase. It is utilized in protein sy... | |||
T36304 | Fluorescein-NAD+ | ||
Fluoroscein NAD+ is a substrate for ADP-ribosylation, providing a convenient non-isotopic alternative to radiolabelled NAD for use in PARP assays. Allows direct measurement of NAD-dependent enzymes, such as PARP, by fluo... | |||
T40345 | AV-153 | ||
AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 al... | |||
T77253 | β-Nicotinamide adenine dinucleotide reduced dipotassium | ||
β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active, reduced coenzyme that functions as a donor of ADP-ribose units in ADP-ribosylation reactions, and as a precursor of cyclic ADP-ribose. It also ... | |||
T60649 | AV-153 free base | ||
AV-153 free base is a 1,4-dihydropyridine (1,4-DHP) derivative. AV-153 free base is an antimutagenic with anti-cancer activity. AV-153 free base interacts with cytosine and thymine and has an influence on poly(ADP)ribosy... |