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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3089 | 6-Thioguanine | 6-TG,2-Amino-6-purinethiol,2-Amino-6-mercaptopurine,Thioguanine | Apoptosis , DNA Methyltransferase , SARS-CoV , Endogenous Metabolite , DUB , Autophagy |
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | |||
T67864 | TH1760 | MKB | NUDIX hydrolase |
TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia ef... | |||
T70304 | CI-898 HCl | ||
CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1... |