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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2158 | Nutlin-3 | Nutlin3 | E1/E2/E3 Enzyme |
Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells. | |||
T6023 | Nutlin-3a | (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3 | Apoptosis , E1/E2/E3 Enzyme , Autophagy |
Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein. | |||
T6614 | Nutlin-3b | (+)-Nutlin-3 | Mdm2 , E1/E2/E3 Enzyme |
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. | |||
T1798 | RITA | NSC 652287,RITA (NSC 652287) | Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy |
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction. | |||
T36464 | Caylin-1 | ||
Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 posit... | |||
T17873 | (4R,5S)-nutlin carboxylic acid | E3 ligase Ligand 15,MDM2 ligand 2 | Others |
(4R,5S)-Nutlin Carboxylic Acid (MDM2 Ligand 2), a Nutlin 3-based MDM2 ligand, can be conjugated to a protein-binding ligand via a linker to create PROTACs[1]. | |||
T17874 | Nutlin carboxylic acid | MDM2 ligand 1,E3 ligase Ligand 16 | Others |
Nutlin Carboxylic Acid (MDM2 ligand 1), derived from Nutlin 3, serves as an MDM2 ligand. It can be attached to a protein ligand via a linker to create PROTACs[1]. | |||
T17902 | Nutlin-C1-amido-PEG4-C2-N3 | E3 ligase Ligand-Linker Conjugates 48,MDM2 Ligand-Linker Conjugates 1 | Others |
Nutlin-C1-amido-PEG4-C2-N3 is a novel compound that functions as a ligand-linker conjugate for the E3 ligase. It is a synthesized molecule incorporating the MDM2 ligand derived from Nutlin 3, and a 4-unit PEG linker. Thi... | |||
T36465 | Caylin-2 | ||
Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for... | |||
T36192 | CAY10682 | ||
(±)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 is a pyrrolo[3,4c]p... |