Co-inhibitory Immune Checkpoint Proteins

Inhibitory checkpoint molecules play an important role in the maintenance of immune homeostasis: their expression on effector T cells ensures the proper contraction of effector T cell responses; their expression on regulatory T (Treg) cells promotes the suppressive function of Tregs. Blockade of inhibitory immune checkpoint molecules has proven to enhance immune responses to various cancers and exhibit remarkable clinical efficacy in cancer treatment.

Cat No.	product name / Synonyms	Species	Expression System
TMPK-00622	CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi) CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
TMPK-00622	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell ...
TMPK-00623	CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi), Biotinylated CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
TMPK-00623	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell ...
TMPK-00624	CD200R1/CRTR2 Protein, Human, Recombinant (hFc) CD200R1/CRTR2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
TMPK-00624	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell ...
TMPK-00644	CD47 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) CD47 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)	Cynomolgus,Rhesus	HEK293 Cells
TMPK-00644	CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 ...
TMPK-00651	SLAMF6 Protein, Cynomolgus, Recombinant (His) SLAMF6 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
TMPK-00651	SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobul...
TMPK-00653	B7-2 Protein, Cynomolgus, Recombinant (His) B7-2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
TMPK-00653	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-00662	PD-L1 Protein (Primary Amine Labeling), Cynomolgus/Rhesus macaque, Recombinant (His), Biotinylated PD-L1 Protein (Primary Amine Labeling), Cynomolgus/Rhesus macaque, Recombinant (His), Biotinylated	Cynomolgus,Rhesus	HEK293 Cells
TMPK-00662	B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been ident...
TMPK-00688	PD-1 Protein, Canine, Recombinant (aa 25-170, hFc) PD-1 Protein, Canine, Recombinant (aa 25-170, hFc)	Canine	HEK293 Cells
TMPK-00688	Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's resp...
TMPK-00733	CD200 Protein, Mouse, Recombinant (aa 31-232, His) CD200 Protein, Mouse, Recombinant (aa 31-232, His)	Mouse	HEK293 Cells
TMPK-00733	CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with...
TMPK-00813	FGL2 Protein, Mouse, Recombinant (His & Avi, Flag) FGL2 Protein, Mouse, Recombinant (His & Avi, Flag)	Mouse	HEK293 Cells
TMPK-00813	Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun...
TMPK-00814	FGL2 Protein, Mouse, Recombinant (His & Avi, Flag), Biotinylated FGL2 Protein, Mouse, Recombinant (His & Avi, Flag), Biotinylated	Mouse	HEK293 Cells
TMPK-00814	Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun...
TMPK-00875	CD96 Protein, Human, Recombinant (His & Avi), Biotinylated CD96 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
TMPK-00875	The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in ...
TMPK-00880	B7-2 Protein, Human, Recombinant (His & Avi) B7-2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
TMPK-00880	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-00881	B7-2 Protein, Human, Recombinant (His & Avi), Biotinylated B7-2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
TMPK-00881	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-00882	B7-2 Protein, Human, Recombinant (hFc) B7-2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
TMPK-00882	B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-00958	BTN1A1 Protein, Human, Recombinant (His & Avi) BTN1A1 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
TMPK-00958	Butyrophilin 1A1 (BTN1A1) is one of the membrane proteins that surrounds LD,BTN1A1 plays an important role in regulating LD synthesis via a mechanism involving m...
TMPK-00968	FGL2 Protein, Human, Recombinant (His & Avi, Flag) FGL2 Protein, Human, Recombinant (His & Avi, Flag)	Human	HEK293 Cells
TMPK-00968	Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun...
TMPK-00969	FGL2 Protein, Human, Recombinant (His & Avi, Flag), Biotinylated FGL2 Protein, Human, Recombinant (His & Avi, Flag), Biotinylated	Human	HEK293 Cells
TMPK-00969	Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun...
TMPK-00970	FGL2 Protein, Human, Recombinant (hFc & Flag) FGL2 Protein, Human, Recombinant (hFc & Flag)	Human	HEK293 Cells
TMPK-00970	Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun...
TMPK-00985	FGL2 Protein, Rat, Recombinant (His & Avi, Flag), Biotinylated FGL2 Protein, Rat, Recombinant (His & Avi, Flag), Biotinylated	Rat	HEK293 Cells
TMPK-00985	Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun...